Expression of endothelin-like immunoreactivity in reactive astrocytes and activation of microglial cells. J Neurol Sci. 1995; 134 :26–32.Zhang M, Olsson Y: Reactions of astrocytes and microglial cells around hematogenous metastases of the human brain. Expression of endothelin-like immunoreactivity in...
To this end, we studied the cellular and molecular mechanisms underlying microglial debris removal. We first screened the major cell types in the brain as potential candidates, including astrocytes, pericytes, endothelial cells, vascular smooth muscle cells (VSMCs), oligodendrocyte precursor cells (OPC...
(extraneuroperikaryal AGE deposits) were significantly abundant in the Alzheimer's brain. In this study, we investigated the spatial relationship of the extraneuroperikaryal AGE (carbocymethyllysine and pentosidine) deposits in astrocytes and microglial cells in the Alzheimer's disease brain using ...
Together with other glial cells, such as astrocytes, NG2 glial cells, and oligodendrocytes16,32,39,40, this neuroinflammatory response increases the noise in electrophysiological recordings, decreases the strength of the neural signal being recorded, and obstructs the tissue–microelectrode integration61....
Interestingly, the pre-stimulation with oAβ(1-42) or the inflammatory and oxidative milieu (IL-1β, LPS or t-BHP) significantly downregulated the fAβ(1-42)-induced mRNA over-expression of CD36, CD47 and Itgb1 receptors in microglial cells. Conclusion These results imply that Aβ ...
Microglia engage in bidirectional communication not only with neurons, but also with astrocytes. Astrocytes are another type of glial cells, but unlike microglia, they are derived from neural stem cells. They are the most abundant glial cells in the CNS and are spread throughout the brain. Ast...
Small extracellular vesicles (sEVs) may play a key role in cell communication by transporting RNA, proteins, and bioactive lipids between cells. Few studies have examined the intercellular communication of astrocytes through sEVs after SCI. The inflammatory signal released from astrocytes is known to...
cells were incubated with FAM-Aβ1-42for 4 h and the amount of phagocytosed FAM-Aβ1-42was measured spectrometrically and normalized to untreated control cells (n = 3 +/- SEM; one-way ANOVA followed by Tukey's post test, ^ P < 0.05 vs. control, ^^^ P < 0.001 vs. control. ...
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease. Nat. Med. 20, 886–896 (2014). CAS PubMed Google Scholar Chang, J. et al. NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation. Proc. Natl Acad. Sci. ...
Glial cells are a family of cells that perform highly specialized roles within the central nervous system of mammals. Microglia, astrocytes and oligodendrocytes are three major sub-types of this family. Microglia have recently been identified to play a central role in modulating synaptic structure, ...