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APOE4dysregulates cholesterol homeostasis in human microglia and astrocytesdoi:10.1038/s43587-022-00256-2Anna KriebsNature AgingNature Publishing Group USNature Aging
Apart from direct mechanisms above, astrocytes can indirectly regulate synapse pruning through initiating microglia [27]. Astrocyte-secreted Interleukin-33 (IL-33) promotes microglial synapse engulfment during neural circuit maturation and remodeling [28]. All in all, astrocytes are involved in the ...
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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell 185, 2213–2233 (2022). Article CAS PubMed Google Scholar Ayhan, F. et al. Resolving cellular and molecular diversity along the hippocampal anterior-to-posterior axis in humans. Neuron 109, 2091–2105 (2021). ...
Concurrent isolation and characterization of oligodendrocytes, microglia and astrocytes from adult human spinal cord A cellular preparation of highly enriched oligodendrocytes was obtained from adult human spinal cord by Percoll gradient centrifugation followed by either ... SR Whittemore,HR Sanon,PM Wood ...
APOE4dysregulates cholesterol homeostasis in human microglia and astrocytes Cholesterol is critical to maintain membrane plasticity, cellular function and synaptic integrity. The neurotrophin Brain-derived neurotrophic factor (BDNF... A Kriebs - 《Nature Aging》 被引量: 0发表: 2022年 Generation of bige...
In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes. In contrast to typical astrocytes, which promote neuronal survival, suppor...
Astrocytes regulate glutamate and ion homeostasis, cholesterol and sphingolipid metabolism and respond to environmental factors, all of which have been implicated in neurological diseases. Astrocytes also exhibit significant heterogeneity, driven by developmental programmes and stimulus-specific cellular responses...
neuroglial cells upregulate neuroprotection and mount an evolutionary conserved active defensive response known as reactive gliosis. These complex adaptive glial changes counteract pathological insults. For example, reactive microglia phagocyte pathogens and cellular debris, reactive astrocytes limit damage by...