Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell 185, 2213–2233 (2022). Article CAS PubMed Google Scholar Krencik, R. et al. Dysregulation of astrocyte extracellular signaling in Costello syndrome. Sci. Transl. Med. 7, 286ra266 (2015). Article Google Scholar ...
APOE4dysregulates cholesterol homeostasis in human microglia and astrocytesdoi:10.1038/s43587-022-00256-2Anna KriebsNature AgingNature Publishing Group USNature Aging
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell 185, 2213–2233 (2022). Article CAS PubMed Google Scholar Ayhan, F. et al. Resolving cellular and molecular diversity along the hippocampal anterior-to-posterior axis in humans. Neuron 109, 2091–2105 (2021). ...
Apart from direct mechanisms above, astrocytes can indirectly regulate synapse pruning through initiating microglia [27]. Astrocyte-secreted Interleukin-33 (IL-33) promotes microglial synapse engulfment during neural circuit maturation and remodeling [28]. All in all, astrocytes are involved in the ...
YAP: transcriptional regulator In the EAE model, mice with YAP-deficient GFAP + astrocytes have reduced TGFβ-signaling in astrocytes, show increased astrocyte and microglia activation and reduced astrocyte proliferation in the optic nerve. The effect is counteracted by pharmacological activation of YAP...
and many genes near these were more highly expressed in the respective subtype (Fig.3aand Supplementary Table4). LMRs in striatal and vSVZ astrocytes occur near genes involved in transport and metabolism of amino acids (Slc1a2andGlul), ions (Slc41a2) and cholesterol (Lcat), among others (...
Concurrent isolation and characterization of oligodendrocytes, microglia and astrocytes from adult human spinal cord A cellular preparation of highly enriched oligodendrocytes was obtained from adult human spinal cord by Percoll gradient centrifugation followed by either ... SR Whittemore,HR Sanon,PM Wood ...
1 Based on their shape, function, and location, glial cells are classified as follows: (1) microglia, the only glial cells of immune origin, which reach the brain through the blood during early development; (2) astrocytes; and (3) Schwann cells and oligodendrocytes, which form myelin layers...
Astrocytes regulate glutamate and ion homeostasis, cholesterol and sphingolipid metabolism and respond to environmental factors, all of which have been implicated in neurological diseases. Astrocytes also exhibit significant heterogeneity, driven by developmental programmes and stimulus-specific cellular responses...
neuroglial cells upregulate neuroprotection and mount an evolutionary conserved active defensive response known as reactive gliosis. These complex adaptive glial changes counteract pathological insults. For example, reactive microglia phagocyte pathogens and cellular debris, reactive astrocytes limit damage by...