It also acts as endogenous regulator of cholesterol synthesis. It is known that CS serves as a substrate for synthesizing other sterol sulfates in the brain. However, the role of CS in neurological insult and brain metabolism is unknown. Our goal in this study is to investigate the ...
Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nature methods 2013; 10: 259–264. Article Google Scholar Nieweg K, Schaller H, Pfrieger FW . Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats. J Neurochem 2009; 109: 125...
transcriptional abnormalities, including low levels of metallothionein-3 (MT3) and genes involved in fatty acid synthesis26. In addition, HD astrocyte pathology extends from function to morphology; in fact, HD astrocytes are structurally abnormal27,28, and astrocyte maturational defects have been descri...
Download all Video S1. Serial Sections of Pyramidal Neuron from CA1 in Hippocampus Was Imaged by FIB-SEM Showing Lipid Particles Enclosed in Membrane-Bound Structure, Related to Figure 3 Table S1. Genes and GO Pathways in Astrocytes Containing LDs, Related to Figure 7 and Figure S7Volume...
Neurosteroids are synthesized from cholesterol in the central nervous system and play an important role in the regulation of nervous system activity. Among neurosteroidogenic enzymes, cytochrome P450c17 catalyzes the conversion of pregnenolone (PREG) into dehydrepiandrosterone (DHEA) via the activity of ...
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supporting it. For example, astrocyte-derived cholesterol has been shown to be a crucial factor in promoting synaptogenesis [9]. Apolipoprotein E (apoE), the major cholesterol carrier in the brain, is mainly synthesized and secreted by astrocytes. APOE polymorphisms are the main genetic determinants...
Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte homeostasis, cell signaling, inflammation, and synapse modula...
Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease J. Biol. Chem., 285 (2010), pp. 26279-26288 View PDFView articleGoogle Scholar Stuendl et al., 2016 A. Stuendl, M. Kunadt, N. Kruse, C. Bartels, W. Moebius, K.M. Danzer, B. Mollenhauer,...
RNA isolation, cDNA synthesis and qPCR assays. The human hippocampus was dissected (approximately 50 mg) using a cryostat and collected for RNA extraction using an RNeasy Lipid Tissue Mini Kit (Qiagen, Toronto, Ontario, Canada) and RNA extraction procedure carried out as described.67 Briefly, ...