We then review and discuss the current literature supporting metabolism as a regulator of microglia function in vitro. Lastly, we evaluate the evidence that metabolism regulates microglia and macrophage phenotype in vivo in models of Alzheimer's disease (AD), stroke, traumatic brain injury (TBI) ...
Mutations in profilin 1 (PFN1), which modulates actin dynamics, are associated with ALS. Here the authors show that expression of ALS-PFN1 is sufficient to induce deficits in human microglia-like cells, including impaired phagocytosis and lipid metabolism, and that gain-of-function interactions be...
et al. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J. Biol. Chem. 279, 41197–41207 (2004). Article CAS PubMed Google Scholar Meyers, E. A. & Kessler, J. A. TGF-β family signaling in neural and neuronal differentiation, development, and function. Cold Spring ...
Metabolism in the progression and metastasis of brain tumors. Cancer Lett. 2022;539: 215713. Article PubMed CAS Google Scholar Longhitano L, Vicario N, Forte S, et al. Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. Cancer ...
Alzheimer’s disease (AD) features progressive neurodegeneration and microglial activation that results in dementia and cognitive decline. The release of soluble amyloid (Aβ) oligomers into the extracellular space is an early feature of AD pathology. Th
The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals and significantly impacts their quality of life. Neuroinflammation, characterized by activation of microglia(MG) and release of cytok
For instance, is TREM2 a key sensor for amyloid-β and other AD-related pathology, or does its loss of function cause developmental defects in microglia that render them unable to change state? Is TREM2 controlling the microglial state by regulating their energetic and anabolic metabolism?122,...
Alzheimer’s disease (AD) is a major public health problem with substantial economic and social impacts around the world. The hallmarks of AD pathogenesis include deposition of amyloid β (Aβ), neurofibrillary tangles, and neuroinflammation. For many years, research has been focused on Aβ accumu...
News & Views24 Jul 2024Nature Metabolism Volume: 6, P: 1426-1428 HDAC3 stokes microglia in stroke George Andrew S. Inglis Research Highlights08 Apr 2024Nature Neuroscience Volume: 27, P: 606 Lysosome regulation of microglia in Alzheimer’s disease via TFEB–vacuolar ATPase ...
There has been an explosion of new findings recently giving us insights into the involvement of microglia in central nervous system (CNS) disorders. A host of new molecular tools and mouse models of disease are increasingly implicating this enigmatic type of nervous system cell as a key player ...