Microglia are a type of small macrophage-like glial cell in the central nervous system. Microglia can engage in phagocytosis, and are involved in immune responses within, as well as the development and remodelling of the nervous system. Their shape varies depending on the developmental and function...
Mutations in profilin 1 (PFN1), which modulates actin dynamics, are associated with ALS. Here the authors show that expression of ALS-PFN1 is sufficient to induce deficits in human microglia-like cells, including impaired phagocytosis and lipid metabolism, and that gain-of-function interactions be...
Central nervous system (CNS) metastases are a major cause of death in patients with cancer. Tumor cells must survive during their migration and dissemination in various sites and niches. The brain is considered an immunological sanctuary site, and thus the safest place for metastasis establishment....
specific pathological mechanisms, such as an inability to explain the delayed effect of antidepressants and a lack of focus on cells other than neurons in the central nervous system (CNS) [6,7]. Microglia are the first line in the innate immune system in the CNS and actively regulate microenv...
Integrative mRNA-miRNA multi-omics analysis highlighted the crucial role of miR-223 in the neuroinflammation process following SCI, potentially through the regulation of lipid metabolism via Abca1. In vitro experiments using BV2 cells overexpressing miR-223 demonstrated that elevated levels of miR-223 ...
Alzheimer’s disease (AD) features progressive neurodegeneration and microglial activation that results in dementia and cognitive decline. The release of soluble amyloid (Aβ) oligomers into the extracellular space is an early feature of AD pathology. Th
To pinpoint α-syn-induced changes in neuronal function, we performed next-generation RNA sequencing on control neurons and neurons exposed to aggregated α-syn. In total, 951 genes were differentially regulated (fold change [FC] ±1.5, false discovery rate [FDR] corrected p value 0.05) in re...
Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health1, it is unknown which
There has been an explosion of new findings recently giving us insights into the involvement of microglia in central nervous system (CNS) disorders. A host of new molecular tools and mouse models of disease are increasingly implicating this enigmatic type of nervous system cell as a key player ...
Aim: The Predictable Results and Experience in Diabetes through Intensification and Control to Target: An International Variability Evaluation (PREDICTIVE... LF Meneghini,KH Rosenberg,C Koenen,... - 《Diabetes Obesity & Metabolism》 被引量: 204发表: 2010年 Mononuclear cells modulate the activity of...