the relationship between lipid metabolism in glia and Alzheimer’s disease pathology remains poorly understood. Through single-nucleus RNA sequencing of brain tissue in Alzheimer’s disease, we have identified a microglial
Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of ...
Alzheimer’s disease (AD) represents profound degenerative conditions of the brain that cause significant deterioration in memory and cognitive function. Despite extensive research on the significant contribution of lipid metabolism to AD progression, th
S. Lipids of nervous tissue: composition and metabolism. Prog. Lipid Res. 24, 69–176 (1985). Article CAS PubMed Google Scholar Söderberg, M., Edlund, C., Kristensson, K. & Dallner, G. Lipid compositions of different regions of the human brain during aging. J. Neurochem. 54, ...
Pathway enrichment analysis and protein-protein interaction network construction were performed using bioinformatics methods, revealing miR-223-Abca1 as a crucial miRNA-mRNA pair in lipid metabolism regulation. BV2 microglia cell lines overexpressing miR-223 were engineered, and immunofluorescence staining, ...
4), as follows: glycine, serine, and threonine metabolism; cysteine and methionine metabolism; riboflavin metabolism; arginine and proline metabolism; pyrimidine metabolism; nicotinate and nicotinamide metabolism. In addition, the following pathways were altered in the hippocampus of the WT plus LPS ...
The risk level model derived from 16 lipid metabolism-associated genes represents a prognostic biomarker for DLBCL that is novel, robust, and may have an immunosuppressive role. It can compensate for the limitations of the IPI score in predicting overall survival and has potential clinical application...
In recent years, an integrated approach of metabolomics and lipidomics has been receiving a great interest in the research field of brain metabolism. Yu et al. developed a parallel metabolomics and lipidomics analytical method to profile region-specific shifts in metabolites and lipids in the brain...
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nature Med. 9, 213–219 (2003). Article CAS PubMed Google Scholar Joseph, S. B. et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl Acad. Sci. USA 99, 7604–7609 (...
However, the cell-specific functions of REV-ERBα in microglia and other glial cells are unknown. Although REV-ERBα is known as a mediator of lipid metabolism in periphery, the exact role of REV-ERBα in lipid metabolism in the central nervous system (CNS), especially in microglia, is ...