Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. These...
These cells, which we call 'lipid-droplet-accumulating microglia' (LDAM), are defective in phagocytosis, produce high levels of reactive oxygen species and secrete proinflammatory cytokines. RNA-sequencing analysis of LDAM revealed a transcriptional profile driven by innate inflammation that is distinct ...
Interestingly, lipid droplet-accumulating microglia (LDAM) have been implicated in conditions such as Alzheimer's disease and aging. Based on this, we hypothesized that SFO LDAM may be a unique contributor to hepatic steatosis during obesity. To investigate this, 6 wk old C57Bl/6J male mice ...
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brainCellular neuroscienceCognitive ageingGlial biologyAn amendment to this paper has been published and can be accessed via a link at the top of the paper....