Whether microglial activation constitutes a primary pathological event in synucleinopathies is not known. Here, the authors generated a mouse model over-expressing α-synuclein in microglial cells and found these mice developed progressive dopaminergic neuron degeneration and microglia developed a reactive,...
Microglia-to-neuron signalling is critically involved in pain hypersensitivity. However, molecules that control microglial cellular state under chronic morphine treatment remain unknown. Here we show that the microglia-specific subtype of Ca2+-activated K+ (BK) channel is responsible for generation of ...
The intermediate-conductance calcium-activated potassium channel KCa3.1 has been reported to modulate the “pro-inflammatory” phenotype of microglia in different pathological conditions. We here investigated the effects of blocking KCa3.1 activity in the hSOD1G93AALS mouse model, which recapitulates ...
Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B (2012) Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74:691–705 ArticlePubMedCAS Schafer DP, Lehrman EK, Stevens B...
Microglia-neuron communication at nodes of Ranvier depends on neuronal activity through potassium release and contributes to myelin repairdoi:10.1101/2020.09.02.279562R. RonzanoT. RouxM. ThetiotM.S. AigrotL. RichardF.X. LejeuneE. MazuirJ.M. Vallat...
Kroner A, Greenhalgh AD, Zarruk JG, Passos Dos Santos R, Gaestel M, David S (2014) TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 83(5):1098–1116. doi:10.1016/j.neuron.2014.07.027 ...
Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation pr
Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing Neuron, 101 (2019), pp. 207-223.e10, 10.1016/j.neuron.2018.12.006 View PDFView articleView in ScopusGoogle Scholar 70 L. Kracht, M. Borggrewe, S. Eskandar, N. Brouwer, S.M. Chuva...
Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination ArticleOpen access01 September 2021 Introduction The modern era of microglia research was jump-started by the report of Blizinger and Kreutzberg in 19681describing the ...
(CNS), utilize their specific receptor repertoire to monitor the microenvironment dynamically in the brain.1Microglia phagocytose misfolded proteins, cellular debris, and dying cells to maintain homeostasis.2Additionally, microglia could monitor and protect neuronal functions through microglia-neuron ...