Microglia are brain macrophages, activated by pathogens, damage or cytokines.Activated microglia kill neurons via TNF伪, cathepsin B, glutamate, NO and oxidants.These agents may also protect neurons, and can only kill in specific circumstances.Stressed neurons can be killed by being phagocytosed ...
Kim W-G, Mohney RP, Wilson B, Jeohn G-H, Liu B, Hong J-S (2000) Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci 20:6309–6316. https://doi.org/10.1523/JNEUROSCI.20-16-06309.2000 Article CAS PubMed Pub...
Human Lifespan May Be Reaching A Temporary Peak Bird Flu a “Single Mutation” Away from Humans Stuck Stem Cells Culprit for Gray Hair This Mouse Has Genes Older Than All Animal Life Memory Isn’t Exclusive To the Brain Scientists May Have Found Why Some 'Hear Voices' ...
(2010) Tumor necrosis factor-alpha mediates the blood–brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells. J. Pharmacol. Sci. 112, 251–254. 3780 C. Larochelle et al. / FEBS Letters 585 (2011) 3770–3780 [189] Hashioka, S., Klegeris, ...
stem cells transplantation, shock and kill strategy, block and lock strategy, gene therapy and combined strategies. We are thankful to Department of Health Research, Ministry of Health & Family welfare, Government of India for providing fellowship to Dr. Shesh Prakash Maurya under DHR-HRD scheme....
3091 kinase activity in the murine hippocampal neuronal cell line, HT22 cells, and immature neurons [121]. The neurotrophin receptor, TrkB, is required for neu- ronal survival and differentiation as well as synaptic struc- ture, function, and plasticity [125, 126]. As a consequence, ...