其产物称 tapasin,即 TAP 相关蛋白 (TAP- associated protein),对 I 类分子在内质网中的装配起作用,参与内源性抗原的 加工和提呈。上述抗原加工提呈相关基因全部坐落在 HLA 系统的II类基因区。 1.2.3 非经典I类基因 非经典I类基因又称 HLAIb,即 b 型I类基因,包括 HLA-E、HLA-F、 HLA-G 等。与之相对...
the functions of the non-polymorphic MHC class I molecules (MHC class Ib molecules) have been elusive, but emerging evidence reveals that, in addition to antigen presentation, MHC class Ib molecules are involved in immunoregulation. As we discuss here, the subset of MHC class Ib molecules that...
Table 1 Sequence motif unique to CD14 specific class I alleles Full size table Differential protein expression of Mafa-B*134:02 Although we demonstrated that certain MHC class I sequences were regulated differentially at the transcript level, it was not clear whether this differential transcription ...
Universal, open MHC-I for rapid ligand loading and enhanced complex stability across classical and non-classical allotypes.doi:10.4049/jimmunol.210.Supp.251.15The instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, or ...
CIITA exerts its activity through this multiprotein complex. Both regulatory modules contribute to the constitutive and inducible level of MHC class I genes in most nucleated cells. In the MHC class Ib promoters, these conserved regulatory sites can also be recognized but they display nucleotide ...
Two large families of G protein-coupled receptors have been identified as candidate pheromone receptors in mammals. Recent work now implicates another surprising family in pheromone recognition. Genes belonging to the major histocompatibility complex (MHC) class Ib, best known for their role in self-...
Major histocompatibility complex class I (MHC-I) molecules are cell surface proteins essential for antigen presentation1. MHC-I encoded by three gene loci (HLA-A, -B, and -C) are composed of a polymorphic heavy α-chain and an invariant β-2 microglobulin light chain9. The α1- and α...
1、 第六章第六章 主要组织相溶性抗原主要组织相溶性抗原 复合体复合体 major histocompatibility antigen complex,mhc mhc h-2复合体复合体 hla复合体复合体 小鼠小鼠h-2分子分子 人类人类hla分子分子 主要组织相溶性抗原系统引起主要组织相溶性抗原系统引起急而强急而强的器官移植排斥反应的器官移植排斥反应 编码...
MHC class I molecules adopt a peptide-receptive conformation that is highly unstable until the peptide binds. To help stabilize them, MHC class I molecules are recruited into a multimericprotein complextermed the peptide-loading complex, in which stable MHC class I–peptide complexes are preferentiall...
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. Humans have MHC class I molecules comprising the classical (MHC-Ia) HLA-A, HLA-B, and HLA-C, and the non-classical (MHC-Ib) HLA-E, HLA-F,...