Colledge L, Bennett CL, Reay PA et al (2002) Rapid constitutive generation of a specific peptide-MHC class II complex from intact exogenous protein in immature murine dendritic cells. Eur J Immunol 32:3246–3255Colledge L,Bennett CL,Reay PA.Rapid constitutive generation of a specific peptide-...
除了HLA,MHC class II基因还有其他一些别称,如DC (differentiation cluster)基因、LMP(Low molecular weight protein)基因、TAP (transporter associated with antigen processing)基因和DMA (DMα)、DMB (DMβ)基因。 1. HLA基因家族: MHC class II基因最广为人知的别称是HLA基因。HLA基因分为HLA class II和HLA ...
MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the ant...
MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a...
Description: The M5/114.15.2 monoclonal antibody reacts with the mouse major histocompatibility complex class II, both I-A and I-E subregion-encoded glycoproteins (I-A b, I-A d, I-A q, I-E d, I-E k, not I-A f, I-A k, or I-A s). It detects a...
Description: The M5/114.15.2 monoclonal antibody reacts with the mouse major histocompatibility complex class II, both I-A and I-E subregion-encoded glycoproteins (I-A b, I-A d, I-A q, I-E d, I-E k, not I-A f, I-A k, or I-A s). It detects a polymorphic ...
During the time of any infection, for example, consider a viral infection, the cell happens to release a foreign protein. At this time, as part of the MHC class I will exhibit these peptides on the cell surface. As a result, the CTLs that are specific for the MHC peptide complex will...
蛋白别名:H-2 class II histocompatibility antigen, A beta chain; histocompatibility 2, class II antigen A, beta 1; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1 ...
MHC class II is unclear. Other tumors secrete inhibitory cytokines like IL-10 to suppress MHC class II and other responses, which is particularly clear for melanomas (Dummeret al., 1996) and EBV-induced B cell tumors (Benjaminet al., 1992). TheEBVgenome encodes a homologous protein for ...
MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a...