Stabilization of blood methylmalonic acid level in methylmalonic acidemia afterChen PW, Hwu WL, Ho MC, Lee NC, Chien YH, Ni YH, Lee PH. Stabilization of blood methylmalonic acid level in methylmalonic acidemia after liver transplantation. Pediatr Transplant. 2010; 14 :337–341....
Methylmalonic acid AMI: Acute myocardial infarction I/R: Ischemia–reperfusion ROS: Reactive oxygen species H/R: Hypoxia/reoxygenation EF: Ejection fraction FS: Fractional shortening GPX4: Glutathione peroxidase 4 SLC7A11: Solute carrier family 7 member 11 Fer-1: Ferrostatin-1 RSL3:...
Uremia (UR) is caused by increased UR-related toxins in the bloodstream. We explored the mechanism of enterogenous toxin methylmalonic acid (MMA) in calcium-phosphorus metabolic disorder in UR rats via the Wnt/β-catenin pathway. The UR rat model was est
26 During the perioperative fasting period, an infusion of 10% dextrose is typically started at a rate of 1.5 times the normal maintenance rate (by weight to approximate a glucose infusion rate of 8 mg/kg/min) while monitoring blood glucose levels and acid-base balance.27, 28, 29, 30 ...
These disruptions result in the abnormal accumulation of 3-hydroxypropionic acid, methylcitric acid, and methylmalonic acid in blood and urine [11]. MMA is the most prevalent organic acidemia in children [21], and affected individuals often suffer from multi-organ damage, with potentially life-...
For example, an improvement in clinical symptoms and a significant (> 50%) reduction in the blood C3/C2 ratio and urinary methylmalonic acid level after the vitamin B12 loading test are considered indicative of complete responsiveness. If the blood C3/C2 ratio and urinary methylmalonic acid ...
The questionnaire asked for clinical presentation and major complications (e.g. metabolic stroke, CRF, and pancreatitis), anthropometrics, blood pressure, routine laboratory tests (including complete blood cell count, serum creatinine, serum uric acid, and urinary MMA concentration), results of cranial...
methylmalonic acid, and total homocysteine concentrattons. A m J Hematol 34:VY-107 II. Stabler SP, Allen RH, Savage DG, Lindenhaum J IV'H1Cltntcal spectrum and diagnosis o f cobalamin deficiency. Blood 76:871+XI 12. Carmel R IW Subtle and atypical cohalamin deticiency states. A m ...
Propionic acidemia (PROP) is an autosomal recessive inherited metabolic disorder (OMIM 606054) caused by defective functioning in the mitochondrial enzyme, propionyl CoA carboxylase (PCC), resulting in the accumulation of propionic acid metabolites, and dysfunction in the respiratory chain and urea cycle...
(TCN2), the major blood transporter of B12. High creatinine reflects kidney dysfunction, and can affect levels of homocysteine and methylmalonic acid. In the absence of kidney dysfunction, abnormally high homocysteine is a marker of B12 and/or folate deficiency while raised methylmalonic acid ...