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Methylmalonic acid (MMA) and total homocysteine (tHCYS) concentrations are used to detect acquired and inborn errors of cobalamin (vitamin B12, Cbl) metabolism and to evaluate the effect of therapeutic interventions. Dried blood spot sampling offers a patient-friendly and easy alternative to plasma ...
(Chemistry) potential of hydrogen; a measure of the acidity or alkalinity of a solution equal to the common logarithm of the reciprocal of the concentration of hydrogen ions in moles per cubic decimetre of solution. Pure water has a pH of 7, acid solutions have a pH less than 7, and alk...
In patients with vitamin B12 deficiency, homocysteine and methylmalonic acid concentrations are markedly increased, while patients with folate deficiency will show increased homocysteine concentrations [21]. Hypersegmented neutrophils are also often seen in megaloblastic anemia [4]. Macrocytic anemia may ...
B12 deficiency: Elevated methylmalonic acid (conversion to succinyl coA requires B12), reduced serum B12, subacute degen. of spinal cord (poor proprioception and spastic paralysis).7 Why is subacute combined degeneration of the spinal cord seen in vitamin B12 deficiency?
Frobish and Davis45 proposed that an accumulation of methylmalonic acid in the blood of cows could increase the amount of propionate presented to the liver for metabolism, which might subsequently increase gluconeogenesis. In the present study, however, less methylmalonic acid was detected in the ...
sex, BMI, race, education status, physical activity, marital status, poverty-to-income ratio, current smoking, alcohol intake, serum cotinine, blood cadmium, Serum Vitamin B12, Serum folate, Serum uric acid, eGFR, C-reactive protein, Vitamin B12 intake, Vitamin B6 intake and Folic acid intake...
Methylmalonic acidemia is an autosomal recessive metabolic disorder in patients with elevated levels of methylmalonic acid. Which vitamin deficiency can lead to this disorder? Briefly explain your answer. Explain the following endocrine disorders....
Determination of Cytokines and Oxidative Stress Biomarkers in Cognitive Impairment Induced by Methylmalonic Acidemia 2021, NeuroImmunoModulation Acupuncture at LR3 and KI3 shows a control effect on essential hypertension and targeted action on cerebral regions related to blood pressure regulation: a resting ...
Urinary organic acids by gas chromatography-mass spectrometry can reveal lactate and Krebs metabolites. Methylmalonic aciduria orientates to a few genes known to induce mitochondrial depletion (seemolecularparagraph). When screening tests are negative, RCD may be misdiagnosed. For this reason, the inves...