Plasma Methylmalonic AcidOBJECTIVES: To examine the reasons why general practitioners (GPs) request plasma methylmalonic acid (MMA) tests and how they respond to a result above the reference interval. DESIGN: Retrospective study of medical records. SETTING: Primary health care, Aarhus County, Denmark...
This strategy is likely to promote over-treatment with vitamin B-12.Keywords:General Practice,聽Diagnostic Decision,聽Vitamin B-12 Deficiency,聽Vitamin B-12,聽Plasma Methylmalonic Aciddoi:10.1080/028134302317282761Anne-MetteDepartmentHvasDepartment
FullText Abstract To the Editor.—In a recent Questions and Answers section, Dr Upshaw1asked which test to use to establish true functional vitamin B12deficiency. Dr Carmel, in reply, suggested the serum methylmalonic acid (MMA) assay noting, however, its limitations of expense and specificity....
Ischemia reperfusion Methylmalonic acid Oxidative stress Ferroptosis KEAP1/NRF2Sections Figures References Abstract Introduction Methods Results Discussion Conclusion Availability of data and materials Abbreviations References Acknowledgements Funding Author information Ethics declarations Additional information Supplementary...
Methylmalonic acidemiaClassification & external resources Methylmalonic acid ICD-10 E71.1 ICD-9 270.3 DiseasesDB 29509 29510 MedlinePlus 001162 eMedicine neuro/576 Methylmalonic acidemia ("MMA"), also called methylmalonic aciduria, is an autosomal genetic disorder affecting branched-chain amino a...
The condition is caused by mutations in the methylmalonyl-CoA mutase (MCM) gene or its cofactor, adenosylcobalamin (AdoCbl), leading to disruptions in the metabolic pathways of propionic acid precursor amino acids (valine, isoleucine, threonine, methionine), as well as propionate, odd-chain fatty...
For example, an improvement in clinical symptoms and a significant (> 50%) reduction in the blood C3/C2 ratio and urinary methylmalonic acid level after the vitamin B12 loading test are considered indicative of complete responsiveness. If the blood C3/C2 ratio and urinary methylmalonic acid ...
Uremia (UR) is caused by increased UR-related toxins in the bloodstream. We explored the mechanism of enterogenous toxin methylmalonic acid (MMA) in calcium-phosphorus metabolic disorder in UR rats via the Wnt/β-catenin pathway. The UR rat model was est
Propionic acidemia (PROP) is an autosomal recessive inherited metabolic disorder (OMIM 606054) caused by defective functioning in the mitochondrial enzyme, propionyl CoA carboxylase (PCC), resulting in the accumulation of propionic acid metabolites, and dysfunction in the respiratory chain and urea cycle...
Methylmalonic Acid and Homocysteine in Plasma as Indicators of Functional Cobalamin Deficiency in Infants on Macrobiotic Diets J. SCHNEEDE, P. C. DAGNELIE, W. A. VAN STAVEREN, S. E. VOLLSET, H. REFSUM, A N D P. M. UELAND Departmer~tof Pharmacology arzd Toxicology, University of Bergen...