The utility of methylmalonic acid, methylcitrate acid, and homocysteine in dried blood spots for therapeutic monitoring of three inherited metabolic diseasesdoi:10.3389/fnut.2024.1414681Yi LiuXue MaLulu KangYing JinMengqiu LiJinqing SongHaixia Li...
Methylmalonic acid (MMA) is a substance produced from the breakdown of amino acids, odd-chainfatty acidsand cholesterol in the body. MMA concentration in blood is reported to be elevated in patients with heart diseases and kidney impairment, and higher plasma MMA is considered a marker of vitami...
Uremia (UR) is caused by increased UR-related toxins in the bloodstream. We explored the mechanism of enterogenous toxin methylmalonic acid (MMA) in calcium-phosphorus metabolic disorder in UR rats via the Wnt/β-catenin pathway. The UR rat model was est
If the blood C3/C2 ratio and urinary methylmalonic acid levels decrease by < 50% but > 30%, it was deemed as partly vitamin B12 responsive [24]. Otherwise, the injection of vitamin B12 was considered non-responsive if a decreased value in the blood C3/C2 ratio and urinary ...
Ferroptosis is a regulatory cell death process pivotal in myocardial ischemia–reperfusion (I/R) injury. However, the precise mechanism underlying myocardial ferroptosis remains less known. In this study, we investigated the pathophysiological mechanisms of methylmalonic acid (MMA) associated with ferroptosi...
These disruptions result in the abnormal accumulation of 3-hydroxypropionic acid, methylcitric acid, and methylmalonic acid in blood and urine [11]. MMA is the most prevalent organic acidemia in children [21], and affected individuals often suffer from multi-organ damage, with potentially life-...
26 During the perioperative fasting period, an infusion of 10% dextrose is typically started at a rate of 1.5 times the normal maintenance rate (by weight to approximate a glucose infusion rate of 8 mg/kg/min) while monitoring blood glucose levels and acid-base balance.27, 28, 29, 30 ...
Methylmalonic Acid and Homocysteine in Plasma as Indicators of Functional Cobalamin Deficiency in Infants on Macrobiotic Diets J. SCHNEEDE, P. C. DAGNELIE, W. A. VAN STAVEREN, S. E. VOLLSET, H. REFSUM, A N D P. M. UELAND Departmer~tof Pharmacology arzd Toxicology, University of Bergen...
In adults, total homocysteine (tHcy) and methylmalonic acid (MMA) in serum or plasma are sensitive markers of cobalamin status and are used for the diagnosis and follow-up of cobalamin deficiency (1, 2, 3). tHcy is also elevated in folate deficiency and is used as an indicator of this ...
The questionnaire asked for clinical presentation and major complications (e.g. metabolic stroke, CRF, and pancreatitis), anthropometrics, blood pressure, routine laboratory tests (including complete blood cell count, serum creatinine, serum uric acid, and urinary MMA concentration), results of cranial...