Simple Sample Preparation for Measuring Methylmalonic Acid in Blood Serum by LC-APCI-MS / MSAs shown in Figure 4, the desired analytical range from 50 to 1,000 nM(5.9 to 118 ng/mL) was consistently achieved using the quantifying MS/...
Methylmalonic acid AMI: Acute myocardial infarction I/R: Ischemia–reperfusion ROS: Reactive oxygen species H/R: Hypoxia/reoxygenation EF: Ejection fraction FS: Fractional shortening GPX4: Glutathione peroxidase 4 SLC7A11: Solute carrier family 7 member 11 Fer-1: Ferrostatin-1 RSL3:...
Uremia (UR) is caused by increased UR-related toxins in the bloodstream. We explored the mechanism of enterogenous toxin methylmalonic acid (MMA) in calcium-phosphorus metabolic disorder in UR rats via the Wnt/β-catenin pathway. The UR rat model was est
The questionnaire asked for clinical presentation and major complications (e.g. metabolic stroke, CRF, and pancreatitis), anthropometrics, blood pressure, routine laboratory tests (including complete blood cell count, serum creatinine, serum uric acid, and urinary MMA concentration), results of cranial...
26 During the perioperative fasting period, an infusion of 10% dextrose is typically started at a rate of 1.5 times the normal maintenance rate (by weight to approximate a glucose infusion rate of 8 mg/kg/min) while monitoring blood glucose levels and acid-base balance.27, 28, 29, 30 ...
had high cognitive function. Among those who developed dementia within 6.39 years, all with raised serum homocysteine (>15μmol/L) at study entry also had co-occurring raised methylmalonic acid (>350nmol/L), high creatinine (>87μmol/L) and transcobalamin II 766G homozygosity. The odds ...
11. Relative sensitivities o f serum cohalamin. methylmalonic acid, and total homocysteine concentrattons. A m J Hematol 34:VY-107 II. Stabler SP, Allen RH, Savage DG, Lindenhaum J IV'H1Cltntcal spectrum and diagnosis o f cobalamin deficiency. Blood 76:871+XI 12. Carmel R IW Subtle ...
The MMAB cells produced little ATR, showed reduced residual ATR activity, and had higher concentrations of methylmalonic acid compared to healthy HLCs. Differential proteome analysis revealed the two MMAB HCLs to show reproducible differentiation, but this was not so for the healthy HLCs. ...
Methylmalonic and propionic acidemia (MMA/PA) are inborn errors of metabolism characterized by accumulation of propionic acid and/or methylmalonic acid due to deficiency of methylmalonyl-CoA mutase (MUT) or propionyl-CoA carboxylase (PCC). MMA has an est
Serum methylmalonic acid and total homocysteine in patients with suspected cobalamin deficiency: a clinical study based on gastrointestinal histopathological findings. American journal of hematology. 1997;56(4):230-8. Epub 1997/12/12.Lindgren A, Swolin B, Nilsson O, Johansson KW, Kilander AF. ...