Epithelial to mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose their cell to cell adhesion and detach from the base of the membrane. EMT is a fundamental process which occurs during tumor progression and metastasis. Cancer genomics is a complex network which involves a ...
间质表皮转化因子 (c-Mesenchymal-epithelial transition factor, c-Met)是受体酪氨酸激酶的一种,较早就被发现在肿瘤细胞的活动中起到重要作用。这个蛋白对于肿瘤研究领域来说并不陌生,早在2008年,Nature Review Drug Discovery就发表过一篇关于c-Met抑制剂的详细综述[1]。这么多年,涉及c-Met靶点的项目并不在少数,...
Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing. J Gastrointest Surg 2010;14:388-97.Hotz B, Visekruna A, Buhr HJ, Hotz HG (2010) Beyond epithelial to mesenchymal transition: a novel role for the transcription factor...
Epithelial-mesenchymal transition is abiological processthat allows a polarized epithelial cell, which normally interacts withbasement membranevia its basal surface and with surrounding cells, to undergo multiple biochemical changes that enable it to assume a mesenchymal cell phenotype. This phenotype include...
Epithelial–mesenchymal transition (EMT) is crucial in embryogenesis and can be exploited by cancer cells to gain metastatic abilities. A hallmark of EMT is E-cadherin loss. In 2000, Snail was reported as the first E-cadherin repressor identified in the context of EMT, advancing our understanding...
Mesenchymal-to-epithelial transition (MET) is an important step in cell reprogramming from fibroblasts (a cell type frequently used for this purpose) to various epithelial cell types. However, the mechanism underlying MET induction in fibroblasts remains to be understood. The present study aimed to ...
上皮细胞间质转型（epithelial-mesenchymal transitions,EMT）是具有极性的上皮细胞转换成为具有活动能力的间质细胞并获得侵袭和迁移能力的过程,它存在于人体多个生理和病理过程中。EMT的发生涉及到多个信号转导通路和复杂的分子机制,与钙连接素、生长因子、转录因子、微环境等有关。EMT与肿瘤细胞的侵袭和转移...
Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing[J]. J Gastrointest Surg,201O, 14(2) :388-97.Hotz B, Visekruna A, Buhr HJ, et al. Beyond epithelial to mesenchymal transition: a novel role for the transcription ...
Epithelial-to-mesenchymaltransition;Meta- staticgrowth;Embryonicsignalingpathways;Transcrip- tionfactors;Cancer Coretip:Thisreviewarticlediscussesthemechanistic regulationofembryonicsignalingpathwayswithaspe- cialfocusonepithelialmesenchymaltransition(EMT)- activatingtranscriptionfactorsincancerprogression viamodulatingthe...
解析 epithelial-to-mesenchymal transition 上皮细胞向间充质细胞转化; 分析总结。 上皮细胞向间充质细胞转化结果一 题目 epithelial-to-mesenchymal transition是什么意思 答案 epithelial-to-mesenchymal transition上皮细胞向间充质细胞转化; 相关推荐 1epithelial-to-mesenchymal transition是什么意思 ...