Using MDCK-MDR1 cells (a transfected cell line overexpressing human P-glycoprotein (multidrug resistance 1; MDR1)) to evaluate whether your compound is a substrate of the P-glycoprotein (P-gp) efflux transporter is crucial in early drug discovery/development as such knowledge feeds into both: ...
cell modelThis article introduces the characteristics and establishment of MDCK-MDR1 cell line,and its applications as an in vitro model for the assessment of the membrane permeability properties of drugs.MDCK-MDR1 cell model is widely used in drug screenings,and the study ...
MDR1cellmodelanditsapplications toscreendrugpermeability LIUYao,ZENGSu (CollegeofPharmaceuticalSciences,ZhangUniversity,Hangzhou310058,China) Abstract:ThisarticleintroducesthecharacteristicsandestablishmentofMDCK—MDR1cellline.and itsapplicationsasaninvitromodelfortheassessmentofthemembranepermeabilitypropertiesofdrugs. ...
This article introduces the characteristics and establishment of MDCK-MDR1 cell line, and its applications as an model for the assessment of the membrane permeability properties of drugs. MDCK-MDR1 cell model is widely used in drug screenings, and the study of mechanisms of drug interaction and...
摘要 本文介绍了MDCK-MDR1细胞系的特点、模型的建立,药物在其细胞模型上吸收转运的研究进展。概述了国内外关于利用MDCK-MDR1细胞系作为模型进行药物筛选、药物相互作用和研究药物吸收转运机制等方面的内容。MDCK-MD...展开更多 This article introduces the characteristics and establishment of MDCK-MDR1 cell line, ...
This article introduces the characteristics and establishment of MDCK-MDR1 cell line, and its applications as an model for the assessment of the membrane p... 曾苏 - 《药学学报》 被引量: 0发表: 0年 应用MDCK-MDR1细胞模型研究3-乙酰基-11-羰基-b-乙酰乳香酸经血脑屏障的通透性 目的:考察3-乙...
andestablishmentofMDCK-MDR1 cellline, anditsapplicationsasaninvitromodelfortheassessmentofthemembranepermeabilitypropertiesofdrugs.MDCK-MDR1 cellmodeliswidelyusedindrugscreenings, andthestudyofmechanismsofdruginteractionandabsorptionortransport.ThereviewsummarizestheprogressandapplicationsofMDCK-MDR1 cellmodel.Because...
of multiple substrates: influenceofcell andmodulatorconcentrationon 尽管如此,MDCK.MDRl细胞用途广、作用大、 line P—gP Metab activity[J].JDrug 实验周期短,是很有前景的实验模型,需要在今后的 1687. 实验中进一步完善和发展。 a1.Evaluationof JD,WeinsteinK,et [15]WangQ,Rager forthe theMDR—MDCKcell...
MDCKII–MDR1 cell line has been extensively selected as a model to study P-gp-mediated drug efflux. Recently, investigators have employed this cell line for studying influx of peptide prodrug derivatives of parent compounds, which are P-gp substrates. Therefore, the objective of this study is ...
(a well-recognized efflux transporter in many tissues and organs such as the brain, kidney, and intestine). MDR1-MDCK permeability assay is one of the drug absorption screening methods. This method uses the MDR1-MDCK cell line, a combination of Madin Darby Canine Kidney (MDCK) cells, and ...