andestablishmentofMDCK-MDR1 cellline, anditsapplicationsasaninvitromodelfortheassessmentofthemembranepermeabilitypropertiesofdrugs.MDCK-MDR1 cellmodeliswidelyusedindrugscreenings, andthestudyofmechanismsofdruginteractionandabsorptionortransport.ThereviewsummarizestheprogressandapplicationsofMDCK-MDR1 cellmodel.Because...
AdvancesintheMDCK?MDR1cellmodelanditsapplications toscreendrugpermeability LIUYao,ZENGSu (CollegeofPharmaceuticalSciences,ZhangUniversity,Hangzhou310058,China) Abstract:ThisarticleintroducesthecharacteristicsandestablishmentofMDCK—MDR1 cellline.and itsapplicationsasaninvitromodelfortheassessmentofthemembranepermeabilitypr...
CK—MDR1cellline.and itsapplicationsasaninvitromodelfortheassessmentofthemembranepermea bilitypropertiesofdrugs. MDCK—MDR1cellmodeliSwidelyusedindrugscreenings.andthestudyof mechanismsofdrug interactionandabsorptionortransport.Thereviewsummarizestheprogressa ...
This article introduces the characteristics and establishment of MDCK-MDR1 cell line, and its applications as an model for the assessment of the membrane p... 曾苏 - 《药学学报》 被引量: 0发表: 0年 防己诺林碱调控紫杉醇在MDR1-MDCKⅡ细胞模型中的跨膜转运研究 目的:研究防己诺林碱对紫杉醇在MDR...
of multiple substrates: influenceofcell andmodulatorconcentrationon 尽管如此,MDCK.MDRl细胞用途广、作用大、 line P—gP Metab activity[J].JDrug 实验周期短,是很有前景的实验模型,需要在今后的 1687. 实验中进一步完善和发展。 a1.Evaluationof JD,WeinsteinK,et [15]WangQ,Rager forthe theMDR—MDCKcell...
This article introduces the characteristics and establishment of MDCK-MDR1 cell line, and its applications as an model for the assessment of the membrane permeability properties of drugs. MDCK-MDR1 cell model is widely used in drug screenings, and the study of mechanisms of drug interaction and...
In this study, two widely use human MDR1 cell lines from Borst and NIH labs were evaluated using rodent brain penetration data, and the study suggested that the MDR1-MDCK cell line from NIH lab predicted brain penetration better, particularly for compounds with a high passive permeability. ...
This article introduces the characteristics and establishment of MDCK-MDR1 cell line, and its applications as an model for the assessment of the membrane p... 曾苏 - 《药学学报》 被引量: 0发表: 0年 防己诺林碱调控紫杉醇在MDR1-MDCKⅡ细胞模型中的跨膜转运研究 目的:研究防己诺林碱对紫杉醇在MDR...
(a well-recognized efflux transporter in many tissues and organs such as the brain, kidney, and intestine). MDR1-MDCK permeability assay is one of the drug absorption screening methods. This method uses the MDR1-MDCK cell line, a combination of Madin Darby Canine Kidney (MDCK) cells, and ...
(Gibco 公司, Cat#15140-122)、 不含CaCl2 和 MgCl2的 PBS 缓冲液(Gibco 公司)、荧光素钾 (lucifer yellow dipotassium salt, Sigma 公司)、Amprenavir (GI268188,GlaxoSmithKline 公司)、GF120918 (GlaxoSmithKline 公司)、MDCK-hMDR1 细胞系 (Madin Darby canine kidney cell line over expressing human MDR1, ...