In breast cancer, KHSRP was destabilized by the mutant p53–proteasome axis, indicating the functional realization of KHSRP was under p53 mutation pathway39. Meanwhile, recent studies also demonstrated the pro-oncogenic function of KHSRP in multiple cancers (see introduction). Based on our results,...
MDA-MB-231 human breast carcinoma cells were grown in vitro or injected in nude mice, either subcutaneously, to mimic primary tumor growth, or intravenously, to mimic metastatic spreading. Expression of DLX2, DLX5 and DLX6 was assessed in cultured cells, either treated or not with ET1, tumo...
Mutational activation of p53 in MDA-MB-231 breast cancer cells up-regulates the mevalonate pathway to promote tumor invasiveness. p53 silencing or pharmacological inhibition of HMG-CoA reductase in these cells decreases protein isoprenylation from endogenously synthesized isoprenoids but enhances the use ...
2.2CSN4表达干扰对MDA-MB-231细胞增殖的影响 使用对照组 慢病毒和CSN4干扰组慢病毒 分别感染MDA-MB-231细胞,确认感染效率后,使用CCK-8细胞生长速率试剂盒检测对照组 和CSN4干扰组 的细胞增殖速率。结果显示,在MDA-MB- 231乳腺癌细胞中,相比较对照组,CSN4干扰组的生长速率均显著低于对照shLuc。统计分析表明,CSN...
MDA-MB-231 human breast carcinoma cells were grown in vitro or injected in nude mice, either subcutaneously, to mimic primary tumor growth, or intravenously, to mimic metastatic spreading. Expression of DLX2, DLX5 and DLX6 was assessed in cultured cells, either treated or not with ET1, tumo...
[12]. We also showed that this miRNA was upregulated in MDA-MB-231 and SK-BR-3 cells as well as in all cell lines after cis-Pt. Lack of significant alteration of miR-106a in MCF7 cells after DOX treatment might be associated with the wild type of p53 in those cells, which has ...