Mutation of p53 gene precedes aneuploid clonal divergence in colorectal carcinoma. B J Cancer 1995; 71: 215-8Carder, P. et al., “Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma”, British Journal of Cancer, vol. 71, 1995, pp. 215-218....
of tumor suppressor gene p53 which has been thought to be the "hotspot" of mutation in transformation induced by α particles.Southern blot analysis showed a deletion in exon 5/6 of p53 gene,but there was no mutation in the exon 8/9 of p53 gene.Conclusion\ p53 gene is the "target" ...
Objective To screen the point mutation of p53 gene rapidly by capillary electrophoresis (CE). Methods A simple capillary electrophoresis system for the str... L Ji,H Jing,Q Ru,... - 《Journal of Sichuan University》 被引量: 7发表: 2003年 应用PCR-SSCP 检测转化细胞中 p53 基因突变 应用PCR...
followed by invasion and metastasis. One of the most common changes is mutation of the p53 tumor suppressor gene. The frequency of p53 alterations in lung cancer is highest in small cell and squamous cell carcinomas. A genetic “signature” of the type ...
genemutationObjectives: Autoantibodies against the p53 tumor suppressor protein have been detected in the serum of a proportion of patients with various cancers. The generation of such antibodies has been proposed to be due to either tumor p53 protein accumulation or to the type of p53 gene ...
Inactivation of the p53 gene by either mutation or HPV infection is extremely frequent in human oral squamous cell carcinoma cell lines. Eur J Cancer B Oral Oncol 1994; 30B:338-45.Min BM, Baek JH, Shin KH, Gujuluva CN, Cherrick HM, Park NH. Inacti- vation of the p53 gene by ...
There werc different kinds of inactivation model of p53 gene in the process of develop ment of cancer and transformation of cells. 展开 关键词: 大肠癌 p53基因 单链构型多态性 杂合性丢失Key words Colorectal cancer p53 gene SSCP LOH 年份: 1996 ...
Germline mutations within evolutionary conserved exons of the p53 gene predispose to tumor development in several familial cancer syndromes. We now report identification of a novel p53 mutation affecting the splice acceptor site of exon 6 in the germline DNA of a family with hereditary breast-ovarian...
Jin W,Xu X,Yang T,Hua Z.p53 mutation, EGFR gene amplification and loss of heterozygosity on chromosome 10, 17p in human gliomas. Chinese Medical Journal English Edition . 2000Jin W,Xu X,Yang T,Hua Z.p53 mutation, EGFR gene amplification and loss of heterozygosity on chromosome 10, 17p...
Lack of mutations in the P53 gene exons 5 to 8 in ataxia-telangiectasia 1993, Cancer Genetics and Cytogenetics more Philippe Jonveaux, Roland Berger Lack of mutations in the P53 gene exons 5 to 8 in ataxia-telangiectasia Cancer Genetics and Cytogenetics, Volume 66, Issue 2, April 1993, Pag...