TP53 mutation data was compiled from the TCGA database and previous publications. d and e, RT-qPCR showing CDKN1A expression in the GBM cell lines used for CRISPR screens (d) and the primary patient-derived xenograft GBM cells used for validation (e), as compared with non-malignant human ...
Themutation is a one megabase deletion resulting in abnormal expression of thegene.mice exhibit hypomyelination of the central nervous system and display rapid tremors and seizures as adults. Thelocus on 6q26-27 has also been implicated as a candidate tumor suppressor gene as thelocus maps to a...
An early p53 mutation appears to lead to GBM at an earlier median age but with a better prognosis than wt p53 tumors. (b) Progenitor cells, of the same or different lineage from (A), acquire a PA that does not select for mutation in p53. This PA along with other mutations causes a...
p53 Gene Mutation in B-Cell Chronic Lymphocytic - Blood:在B细胞慢性淋巴细胞血p53基因突变 热度: 相关推荐 论著 (临床研究) P53蛋白过表达和P53基因突变与胶质母细胞瘤 预后关系的Meta分析 丁粉干,张新华,官兵,王中秋 [摘要]目的胶质母细胞瘤(glioblastoma,GBM)是常见的颅内恶性肿瘤,预后不良。寻找与胶质母...
S8, A and B) in addition to the stabilization of p53β/γ isoforms, which would be unaffected by the downstream mutation. To test this, we utilized H2228 (NSCLC), TCCSUP (urinary bladder cancer), and UACC-893 (breast cancer) cells harboring PTCs in p53 exons 9 (H2228) and 10 (...
p53, as a tumor suppressor gene, plays an important role in the growth, development and differentiation of human tis-sue cells by inducing cell apoptosis, regulating cell cycle, regulating DNA repair and inhibiting angiogenesis. A large number of studies have confirmed that p53 mutation is ...
Recently, the MDM2 SNP309 (T -> G variation) was shown to be associated with accelerated tumour formation in p53 mutation carriers. The impact of the... J Tinat,G Bougeard,S Baert-Desurmont,... - 《Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncolog...
RNA-seq analysis detected no mutations in p53, indicating the reduced p53 response is not due to acquired mutation in the p53 protein- coding sequence. Altered p53 chromatin binding in DAXX_KO and ATRX_KO U87 ALT-like cells Since many p53-response genes were affected in both DAXX_KO and ...
et al. Gain of function of a p53 hot spot mutation in a mouse model of Li–Fraumeni syndrome. Cell 119, 861–872 (2004). Article CAS PubMed Google Scholar Hanel, W. et al. Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ...
Importantly, the effects of NFIA on proliferation and apoptosis were independent of TP53 mutation status, a finding especially relevant for GBM, in which TP53 is frequently mutated. Conclusion NFIA is a modulator of GBM growth and migration, and functions by distinct regulation of critical oncogenic...