Macrophage polarizationis a process through which macrophages obtain distinctive functional features as a response to certain stimuli from their niche[1]. This process has a critical impact in tissue repair and maintenance of tissue homeostasis[2]. Macrophage polarization leads to generation of two dist...
inflammatory, oxidative stress, or remodeling transcriptional states [10]. However, the role of macrophages in IBD has not yet been fully elucidated. The aims of this review are to determine the relationship between macrophage polarization and IBD and better understand the role of macrophage polarizat...
states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and ...
下图总结了M2巨噬细胞亚群的刺激物、表面标记物、分泌的细胞因子和生物学功能。 图片来源:Macrophage Polarization in Physiological and Pathological Pregnancy. Front Immunol. 2019 Apr 15;10:792. 在人和小鼠中观察到M1和M2巨噬细胞表型的不同生物学和生理特征 表格数据来源:Macrophage plasticity, polarization, and...
Macrophage polarization has been more recently revisited showing a broader functional repertoire of this cell population, and important differences among intestinal macrophages phenotype and function have been linked to their spatial distribution within intestinal layers13,14. By combining scRNA-seq with the...
Macrophage polarization and plasticity Macrophages become activated following migration into inflamed tissue, where they exhibit a spectrum of polarization states related to their functional diversity. At one end of the spectrum there is the pro-inflammatory M1 and at the other end the anti-inflammatory...
ObjectiveTo investigate the effects of apoptotic bodies (ABs) derived from dental pulp stem cells (DPSCs) on macrophage polarization and inflammation responsein vivo.MethodsHuman DPSCs were extracted, cultured and identified. Staurosporine was used to apoptosis induction and differential methods were perfor...
we examine the role of the mechanically activated cation channel Piezo1 in macrophage polarization and sensing of microenvironmental stiffness. We show that macrophages lacking Piezo1 exhibit reduced inflammation and enhanced wound healing responses. Additionally, macrophages expressing the transgenic Ca2+repor...
macrophage polarization, we compared the sizes of M1 and M2 nuclei to that of M0, a state before polarization. The polarization states were confirmed by expression of iNOS and Arginase-1, as well as their cellular morphology. In response to the M1 polarization signal LPS and IFN-γ, the ...
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapyJae Hong Im, Jon N. Buzzelli, Keaton Jones, Fanny Franchini, Alex Gordon-Weeks, Bostjan Markelc, Jianzhou Chen, Jin Kim, Yunhong Cao & Ruth J. Muschel ...