Estrogen Signaling Contributes to Sex Differences in Macrophage Polarization during AsthmaAllergic asthma is a chronic Th2 inflammation in the lungs that constricts the airways and presents as coughing and whee
M1 macrophage polarization 1. Introduction Asthma is characterized by airway inflammation and immune cell disorder (Hargreave and Nair, 2009; Togias et al., 2010). Neutrophilic asthma is a kind of non-allergic asthma, characterized by an excessive flux of neutrophils into the airway (Choi et al...
However, TSC1-deficient mice are highly resistant to M2-polarized allergic asthma. Inhibition of the mammalian target of rapamycin (mTOR) fails to reverse the hypersensitive M1 response of TSC1-deficient macrophages, but efficiently rescues the defective M2 polarization. Deletion of mTOR also fails ...
Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization Basophils are important in the EAR, but have also been identified in cutaneous and pulmonary LAR, and are found in increased numbers in the lungs of patients who died of ast...
Micro RNA (miRNA) plays important roles in macrophage polarization. However, the manner in which miRNA regulate macrophage polarization in response to dermatophagoides farinae protein 1(Der f1)-induced asthma has not been defined. This study aims to expl
Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases. Pharm. Ther. 239, 108208 (2022). Article CAS Google Scholar Zhang, H. et al. AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production. J. Exp. Med. 219, e20211828 (2022...
The upstream regulators, phenotypes and functions of macrophage polarization Full size image M1 macrophages promote inflammation and are involved in disease progression in a variety of diseases, for example, in certain types of complicated asthma, the action of M1 macrophages results in excessive product...
Cell Communication and Signaling (2024) 22:557 https://doi.org/10.1186/s12964-024-01937-8 Cell Communication and Signaling RESEARCH Open Access Contribution of IL‑17C‑mediated macrophage polarization to Type 17 inflammation in neutrophilic asthma Yuhuan Wen1, Qile Chen1, Hao ...
Macrophage polarization and allergic asthma Transl Res, 191 (2018), pp. 1-14 View PDFView articleView in ScopusGoogle Scholar 11 B.N. Melgert, N.H. ten Hacken, B. Rutgers, W. Timens, D.S. Postma, M.N. Hylkema More alternative activation of macrophages in lungs of asthmatic patients...
Macrophage Polarization in Asthma Macrophage polarizationis defined as a dynamic process by which a macrophage expresses different functional phenotypes in response to different microenvironmental signals.25On exposure to pathogens, the microenvironment in the tissue is altered, which leads to the polarization...