Ly6Chi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology
We found a significant decrease of infiltrated Ly6Chi monocytes in the brain parenchyma. In the blood, adoptively transferred ZsGreen+ Ly6Chi monocytes drastically reduced due to stress-induced homing to the bone marrow. Adrenalectomy (ADX) experiments revealed that monocyte homing is regulated by ...
Characterization of inflammatory monocytes phenotype duringLeishmania donovani infection. (A) Flow cytometric analysis of Ly6ChiLy6G-CD11b+ cells from uninfected andL. donovaniinfected WT mice 30 days post infection. Cells were gated on CD11b+ and analyzed for monocyte/macrophages/DC associated marker...
Conclusion Ly6Chigh monocytes are involved in VILI, which aggravate VILI by activating the MCP-1/CCR2 axis. 【Key words】 Ventilator-induced lung injury; Ly6Chigh monocyte; Monocyte chemotactic protein-1; CC-chemokine receptor 2 Fund program: Key Project of Guangxi Natural Science Foundation (2018...
Here we demonstrate, by using an acute innate model of colitis, that infiltrating Ly6Chi monocytes acquire in the inflamed colonic lamina propria two functionally distinct fates. Instead of giving rise to resident CX3CR1hi macrophages as in the healthy colon, the monocyte infiltrate initially differ...
Ly6Chi monocytes are reprogrammed into PD-L2+ macrophages during T. crassiceps infection. To further confirm that Ly6Chi monocytes give rise to PD-L2+ macrophages during T. crassiceps infection, fluorescently-labeled bone-marrow Ly6Chi monocytes were intravenously transferred into naïve or T...
Inflammation triggers the differentiation of Ly6Chi monocytes into microbicidal macrophages or monocyte-derived dendritic cells (moDCs). Yet, it is unclear whether environmental inflammatory cues control the polarization of monocytes toward each of these fates or whether specialized monocyte progenitor subset...
单核细胞(monocytes)作为机体固有免疫细胞,在炎症及免疫反应中扮演重要角色,它可通过淋巴细胞抗原6C(lymphocyte antigen 6C,Ly6C)的表达不同来区分。Ly6C高表达(Ly6Chigh)的单核细胞具有促炎和抗菌功能,而Ly6C低表达(Ly6Clow)的单核细胞则参与炎症消退和组织修复。巨噬细胞作为吞噬细胞对维持肝脏稳态至关重要,维持肝脏...
Ly6C+ inflammatory monocytes are essential to host defense against Toxoplasma gondii, Listeria monocytogenes and other infections. During T. gondii infection impaired inflammatory monocyte emigration results in severe inflammation and failure to control
were lower than those in the FU group. The percentages of Ly6Chimonocytes in the colonic LP were lower, but those in the spleen were higher in the ATB + FU group than in the FU group. The mRNA levels of colonic CCL8 were reduced in the ATB + FU group. Antibiotic use is ...