Here, using intravital microscopy, we demonstrate that Ly6Clow monocytes are predominantly recruited to the brain vasculature following infection with Cryptococcus neoformans, a fungal pathogen causing meningoencephalitis. The recruitment depends primarily on the interaction of VCAM1 expressed on the brain ...
研究小组进一步证明,白色脂肪组织可以刺激这些变化,实验使用的是高脂肪饮食小鼠的细胞样本。他们还发现,瘦人体内更丰富的棕色脂肪组织可以导致非侵入性Ly6Clow单核细胞的转变。 “我们的研究揭示了高脂肪饮食是如何引发涉及骨髓的体内炎症级联反应的,”Klip总结道...
55 万方数据 摘要 单核/巨噬细胞Ly6clow亚群在心肌梗死后瘢痕形成期的抗炎特性研究 背景及目的: 70多年来,白细胞在心梗后的募集、活化、炎症调控方面不断被研究,研究者 逐渐认识到,炎症反应是心梗后预防心功能恶化衰竭而调控的核心。 单核巨噬细胞是心肌梗死后重要的炎症调控细胞,具有促炎与抑炎的双向功能。 在...
These observations demonstrate that Ly6C(low) mature monocytes can promote tolerance to self Ag contained in apoptotic cells through a PDL-1-dependent mechanism. 展开 关键词: Monocytes Dendritic Cells T-Lymphocytes in vivo 单核细胞 树突细胞 T淋巴细胞 ...
单核细胞(monocytes)作为机体固有免疫细胞,在炎症及免疫反应中扮演重要角色,它可通过淋巴细胞抗原6C(lymphocyte antigen 6C,Ly6C)的表达不同来区分。Ly6C高表达(Ly6Chigh)的单核细胞具有促炎和抗菌功能,而Ly6C低表达(Ly6Clow)的单核细胞则参与炎症消退和组织修复。巨噬细胞作为吞噬细胞对维持肝脏稳态至关重要,维持肝脏...
Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer Antiangiogenic therapy with antibodies against VEGF (bevacizumab) or VEGFR2 (ramucirumab) has been proven efficacious in colorectal cancer (CRC) patients. ... Jung,Keehoon,Heishi,... 被...
Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow monocytes. Alarmins S100A8/A9 locally releas
Conclusion Ly6Chigh monocytes are involved in VILI, which aggravate VILI by activating the MCP-1/CCR2 axis. 【Key words】 Ventilator-induced lung injury; Ly6Chigh monocyte; Monocyte chemotactic protein-1; CC-chemokine receptor 2 Fund program: Key Project of Guangxi Natural Science Foundation (2018...
[中图分类号]R363[文献标识码]ALDLR deficiency promotes the differentiation of CDl lb+Ly6C+monocytes and matu-rationof CDl l c+dendritic cellsTONG Ming.Hon91,ZHANG Wei.Wei3,WANG Xiang-Min92,ZHANG Huan-Huanl,TAO Rang-Xial,LI Yin91,DINGSu.Lin93,YANG Xiang.Don93(1.Clinical Laboratory,2....
Figure 1. Intravital imaging reveals a marginated pool of Ly6Chigh and Ly6Clow monocytes in BM vasculature. (A) Representative 3-dimensional (3D) 2-photon laser scanning microscopy (3D-TPLSM) pictures showing medullar monocytes in the parenchymal and vascular BM compartments of the skull in Mac...