Ly6Chigh是一种侵入肥胖人群脂肪组织的单核细胞。骨髓中Ly6Chigh单核细胞的积累开始于单核细胞在身体其他部位的脂肪组织中形成炎性巨噬细胞之前——单核细胞的成熟形式。 “这些结果表明,高脂肪饮食可以导致骨髓脂肪细胞的重构,破坏单核细胞的正常平衡,并可能...
ConclusionLy6C high monocytes are involved in VILI, which aggravate VILI by activating the MCP-1/CCR2 axis. KEYWORDS: Ventilator-induced lung injury;Ly6C high monocyte ;Monocyte chemotactic protein-1;CC-chemokine receptor 2 Corresponding author: Pan Linghui, Email: moc.qq9190235hlp FUNDING: Key...
There was no significant difference in the parameters mentioned above among the spontaneous breathing group, normal VT group and high VT ventilation 1-hour group. Conclusion Ly6Chigh monocytes are involved in VILI, which aggravate VILI by activating the MCP-1/CCR2 axis. 【Key words】 Ventilator-...
单核细胞(monocytes)作为机体固有免疫细胞,在炎症及免疫反应中扮演重要角色,它可通过淋巴细胞抗原6C(lymphocyte antigen 6C,Ly6C)的表达不同来区分。Ly6C高表达(Ly6Chigh)的单核细胞具有促炎和抗菌功能,而Ly6C低表达(Ly6Clow)的单核细胞则参与炎症消退和组织修复。巨噬细胞作为吞噬细胞对维持肝脏稳态至关重要,维持肝脏...
Ly6C-high monocytes originated in the bone marrow, and the skull bone marrow contribute a higher proportion of these monocytes than neutrophils. The mRNA level of Ccl2 was significantly upregulated after SAH and was greater in CD11b-positive than CD11b-negative cells. Microglial depletion, ...
2B4 controls gut immune homeostasis by promoting IL-1β expression in Ly6Chigh monocytes that trigger IL-22/IL-18-mediated epithelial regenerationImpaired signaling, downstream of 2B4, is associated with colitis in human patients with XLP ; however, the precise mechanism by which 2B4 maintains gut ...
Based on our results, we found a higher ratio of Ly6Chigh monocytes in the blood and heart of IRG1−/− mice. Thus, we further investigated its organ origins. Bone marrow and spleen are the two main peripheral reserve pools of monocytes during inflammation [49, 50]. By detecting the ...
The negative fraction was collected (putative monocytes) and stained for cell sorting with a BD Influx ™cell sorter. Isolated populations of Ly6Chigh monocytes were stained for 20 min with the cell trace proliferation dye eFluor 450 and eFluor 670, respectively (eBioscience), Stained ...
By adoptive transfer of Ly6C(high) and Ly6C(low) monocytes into infected mice, we found that AAM originate primarily from transferred Ly6C(high) monocytes, but that these cells may transition through a Ly6C(low) state and adopt patrolling behavior in the vasculature. Thus, during chronic ...
Generally, high numbers/percentages of circulating monocytes indicate poor clinical prognosis in cancer14,15, suggesting that monocytes in blood may influence tumor development. In melanoma patients, enrichment of circulating monocytes/myeloid-derived suppressor cells (MDSCs) is associated with higher risk...