Ly6Chigh monocytes are short-lived cells that are present in blood circulation. Perivascular macrophages (PM) probably arise from Ly6Clow monocytes and contribute to the maintenance of homeostasis of the perivascular space, mainly via its phagocytic activity. Quiescent microglia (QM) maintain a healthy...
Among monocyte subsets, a high CD14++CD16+ monocyte number was associated with higher rates of cardiovascular events and death. In a multivariate proportional hazards model adjusted for classical cardiovascular risk factors, patients with CD14++CD16+ monocyte numbers in the top quartile were at ...
Interestingly, Ly6C(high) MDCs, isolated from colitic colons, showed up-regulation of iNOS and arginase-1 and were more potent suppressors than those isolated from spleen. On a single-cell level, MDCs inhibited Th1 responses but enhanced generation of foxp3+ T cells. MDCs, cocultured with ...
HPF High-Power Field. Scale bars = ∼200 μm. Full size image Figure 2 Newborn monocytes demonstrate lower adherence and extravasation as compared to adult monocytes. Purified human monocytes from either a newborn or an adult study participant were applied to each confluent TC well to ...
It is likely that decreases in 4~Ca release from bones cultured in high phosphate media occurred independent of osteoclasts (which were inhibited by phosphate) and were due to a direct effect of the monocytes themselves on bone [1, 2]. Cortisol is also an inhibitor of osteoclastic bone ...
However, little is known about the role of non-classical monocytes and non-classical MDMs in the laser-induced CNV model. Non-classical monocytes express high levels of CD43 and Cx3cr1, and low levels of CCR2 and Ly6C [19]. Lack of Cx3cr1 expression in non-classical monocytes impairs ...
The dG ends form G-tetrads, a G-specific non-Watson-Crick conformation composed of four dG in a planar arrangement featuring very high melting tem- peratures and enabling the formation of intermolecular high-molecular-weight agglomerates that can be phago- cytised by pDCs to activate TLR935. ...
Monocytes are key players in healing after MI, but little is known about the role of the cardiac niche in monocyte activation. This study investigated microenvironment‐dependent changes in inflammatory monocytes after MI. RNA sequencing analysis of murine Ly6Chigh monocytes on day 3 after MI ...
In the present study, we show that IL-1 beta, previously known to be a potent inducer of IL-6 in fibroblasts, endothelial cells, and keratinocytes, but not in monocytes, is also a potent inducer of IL-6 in peripheral blood monocytes. High level IL-6 activity that could be neutralized ...
The two monocyte subsets were also characterized by the differential expression of a number of surface markers (Table 1). CX3CR1low monocytes expressed CD62L (L-selectin), Ly6C/G (Gr1), α2 and α4 integrin (VLA2, VLA4), LFA1, and CCR2, while CX3CR1high cells expressed only LFA...