在小鼠BM、血液和脾脏中,FLT3+CD11c细胞在传统的单核细胞片段中鉴定并表达DCs特异性ICAM-3捕获非整联素(DC-SIGN或CD209a),被认为是单核细胞亚群(R2细胞),产生单核细胞来源的dcMildner等人还发现小鼠血液中的Ly6Cint细胞亚群表达DC特...
Reduced Il17a expression distinguishes a Ly6c(lo)MHCII(hi) macrophage population promoting wound healing. J Invest Dermatol 2013;133:783- 792Rodero MP, Hodgson SS, Hollier B et al. Reduced Il17a expression distinguishes a Ly6c(lo)MHCII(hi) macrophage population promoting wound healing. J ...
Pacific orange-conjugated anti-IA/IE; PE-conjugated anti-CD4 or Ly6C; PerCP-Cy5.5–conjugated anti- Ly6C or CD8; PE-Cy7–conjugated mAb to anti-CD11c; allophycocyanin-Cy7-conjugated anti- MHCII, B220 and Ly6G; and allophycocyanin-conjugated anti-CD64 and anti-SIINFEKL/H-2Kb (clone 25...
Identification of kidney CD45intCD11bintF4/80+MHCII+Ly6C macrophages initially masquerading as T cells 喜欢 0 阅读量: 46 作者:SA Lee,S Noel,M Sadasivam,AR Hamad,H Rabb 摘要: Background Mononuclear phagocytic cells (MPCs) have important roles in the pathogenesis of many kidney diseases, ...
In contrast to R848 stimulated monocytes, it is possible that LPS enhances antigen loading on MHC II more than MHC I, as the transcriptional data illustrated that TLR4 ligated Ly6C+monocytes displayed increased gene expression of essential MHC II molecules,H2-AaandH2-Ab1, and the invariant chain...
increases in MHCII and IL12 expression in tumor-associated macrophages and with >90% reductions in IL10 expression in tumor-associated macrophages, dendritic cells (DC), and Ly6C(+) or Ly6G(+) myeloid-derived suppressor cells (MDSC)... C Cekic,Day, Y.-J.,D Sag,... - 《Cancer Researc...
In the tumor, M-MDSC can differentiate into tumor-associated macrophages (TAM) (CD11b+ Ly6Clo F4/80+ MHCII+)17. In tumor-bearing host, myeloid cells are recruited to tumor sites by chemokines produced by the tumor, such as CCL2 and CCL518,19. In chronic tumor-associated inflammation, ...
Shortly after transfer, graft-derived cells were retrieved from the inflamed tissue as Ly6ChiCD11c−MHCII+/− cells. Notably, the colon of DSS-challenged mice was reported to harbor two macrophage populations that can be discriminated according to CX3CR1 expression, TLR profiles, and TNF-α...
By contrast, Flt3CD11cMHCIIPU.1lomonocytes differentiated into FcγRIII+PD-L2CD209aiNOS+macrophages upon microbial stimulation. Importantly,Sfpi1haploinsufficiency genetically distinguished the precursor activities of monocytes toward moDCs or microbicidal macrophages. Indeed,Sfpi1+/mice had reduced Flt3+...
脉络从巨噬细胞(CD11b+CD45hiCD163-MHCIIhi) 6. 小鼠脾脏组织 巨噬细胞也一般用CD11blow、F4/80+作为检测标志物,也可用CD11blow、CD64+作为检测标志物,还特征性表达MerTK,CD68。脾脏里的巨噬细胞细分的话,还可以分为红髓和...