These CD45intCD11bint MPCs were further identified as F4/80+MHCII+CX3CR1+Ly6C- cells, comprising ~17% of total CD45+ cells in normal mouse kidney (P < 0.01) and virtually absent from all other organs examined except the heart. Systemic clodronate treatment had more significant depletive...
Further studies using Fc receptor blockers disclosed that this population was a renal macrophage subset which was different from other macrophages by its intermediate expression of CD45 and CD11b. These CD45intCD11bint macrophages were further characterized as F4/80+MHCII+Ly6C cells comprising 40%...