In patients, increased hepatic uptake of radioactivity was not detected after injection of 68Ga-PSMA-617 [21, 23]. Although 68Ga-labeled PSMA ligands—in particular 68Ga-PSMA-11—are successfully employed in the clinics, it is indisputable that the high cost for a 68Ge/68Ga generator is a...
Tertiary objectives include evaluation of QOL (FACT-P and EQ5D-5L), cost effectiveness, ctDNA and radiographic based prognostic and predictive biomarkers, dosimetry based approach to measurement of [177Lu]Lu-PSMA-617 activity and creation of tissue and image biobanks. Key eligibility criteria ...
(lutetium Lu 177 vipivotide tetraxetan) (formerly referred to as 177Lu-PSMA-617) for the treatment of adult patients with a certain type of advanced cancer called prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer (PSMA-positive mCRPC) that has...
Over recent years, [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced prostate cancer. Especially for alpha particle emitter treatments, there is still a need for improving dosimetry, w
The developed optimized protocol for formulating therapeutic dose of Lu-177-PSMA-617 could be useful for large number of nuclear medicine therapy clinics across the world having access to moderate specific activity Lu-177 at an affordable cost.Chakraborty, SudiptaChakravarty, RubelShetty, PriyalataVi...
The developed optimized protocol for formulating therapeutic dose of 177Lu-PSMA-617 could be useful for large number of nuclear medicine therapy clinics across the world having access to moderate specific activity 177Lu at an affordable cost.doi:10.1002/jlcr.3414...