Sequencing Reagents Microarray Kits Clinical Research Products IVD Products All Kits & Reagents Illumina Single Cell 3' RNA Prep An easy, scalable, and microfluidics-free workflow makes single-cell RNA-Seq (scRNA-Seq) accessible for more labs View kit Selection Tools Library Prep & Array Kit ...
目前这里有大量不同的DNA和RNA修饰,好多都是没有被检测到和研究的,长读长测序为研究这些修饰的分布和功能打开了新的大门。 Lucas, M.C., Novoa, E.M. Long-read sequencing in the era of epigenomics and epitranscriptomics.Nat Methods20, 25–29 (2023).https://doi.org/10.1038/s41592-022-01724-8 ...
2023年1月12号,NatureMethod报道2022年最值得关注的方法——长读段测序(Long-read sequencing)。 今年6月,Nature Method上发表关于一篇T2T的文章,并强调端粒到端粒(T2T)联盟成功地提出了第一个完整的人类基因组。这一成就是通过广泛的实验和计算努力取得的。其中,长读测序是负责生成T2T数据的主要测序技术,可以说为...
其中,precisionFDA的挑战框架是该平台最具开放性的功能之一,它支持在公开环境中举办生物数据挑战,并提供必要的资源以便进行测试和验证。 在2016年,首届瓶中基因组(GIAB)-precisionFDA真相挑战赛正式启幕,挑战参赛者从两个GIAB样本的短读长数据中识别出小变体。虽然HG001(也被称为NA12878)的基准测试数据已提前公布,但当...
Nature Methods 认为，随着技术不断创新进步的步伐，长读长测序实现更长、更准并且更经济高效将是未来值得期待的重点！未来，齐碳科技将不断自主创新，继续向纳米孔基因测序科研无人区挺进，持续提升国产测序仪性能，探索纳米孔测序技术的更多可能性，并加快推动这一高精尖技术真正走入寻常百姓家，为人类健康贡献“中国...
Long-read sequencing, also known as third generation sequencing, is an emerging technique that allows for the sequencing of longer DNA segments leading to improved detection of structural variants and epigenetics. These capabilities are opening a way for better characterization of brain tumors. Here, ...
长读测序(Long-Read Sequencing,LRS),即第三代DNA测序技术,可以绘制更加完整的人类基因组图谱。下一代DNA测序是基因组革命背后的驱动力。虽然短读测序(Short-Read Sequencing,SRS)在过去占主导地位,但ARK认为,长读测序将迅速获取市场份额。 ARK认为,与短读测序相比,长读测序技术可以提供更高的准确性、更全面的变体...
Shotgun DNA sequencing has been used to build contiguous sequence information of entire chromosomes1. However, previous sequencing reads were too short to resolve the order of repetitive sequences, because the repeats were longer than an individual read, or sequence variations between two tandem copie...
The debate between short-read and long-read sequencing is an ongoing one, but it is clear that both technologies have their own unique benefits. For the most comprehensive results, it is best to combine the two together. By doing so, you can get the most complete picture of your data whi...
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a key event in cervical carcinogenesis. Here, we perform comprehensive characterization of large-range virus-human integration events in 16 HPV16-positive cervical tumors using the Nanopore long-read sequencing technolog...