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the budding yeastSaccharomyces cerevisiaehas many isolates currently being sequenced with long reads. However, analyzing long-read sequencing data to produce high-quality genome assembly
Several studies have demonstrated the regulatory roles of read-through transcripts in tumorigenesis and development. However, limited by the read length of next-generation sequencing, discovery of read-through transcripts has been slow. For long but also erroneous third-ge...
尽管长读长测序技术很强大,但也不完美。除了需要努力产生更长、准确率更高的数据,降低成本也是一个主要目标,只有便宜了各个课题组才能够用得起,也才能推动生物学更加蓬勃发展。 Method of the Year 2022: long-read sequencing. Nat Methods 20, 1 (2023). doi.org/10.1038/s41592- ...
As long-read sequencing technologies are becoming increasingly popular, a number of methods have been developed for the discovery and analysis of structural variants (SVs) from long reads. Long reads enable detection of SVs that could not be previously detected from short-read sequencing, but comput...
Nature Methods 2022年年度最佳技术——long-read sequencing 2022年2月，国际顶级期刊Nature发布了【2022年度值得关注的七大顶尖生物技术榜单】，并评述这七大顶尖生物技术有望在本年对科学研究产生重大影响，长读长测序技术赫然在榜。4月，人类基因组测序便迎来第18座里程碑——迄今最完整的人类基因组图谱发布！其中，...
Over the past decade, long-read, single-molecule DNA sequencing technologies have emerged as powerful players in genomics. With the ability to generate reads tens to thousands of kilobases in length with an accuracy approaching that of short-read sequencing technologies, these platforms have proven ...
(Fig.1b). This identified trends in the evolution of research interests: likely due to the modest initial throughput of long-read sequencing technologies, the majority of tools were tested on non-human data; tools for de novo assembly, error correction, and polishing categories have received ...
2022年2月,国际顶级期刊Nature发布了【2022年度值得关注的七大顶尖生物技术榜单】,并评述这七大顶尖生物技术有望在本年对科学研究产生重大影响,长读长测序技术赫然在榜。 4月,人类基因组测序便迎来第18座里程碑——迄今最完整的人类基因组图谱发布!其中,长读长测序正是负责端粒到端粒数据的主要测序技术,以其长读长...
README GPL-3.0 license Nanofilt Filtering and trimming of long read sequencing data. Please be aware that NanoFilt will no longer receive any updates, as (most of) its functionality is included in chopper (which should be lots faster, too). Filtering on quality and/or read length, and optio...