longnon coding rna名词解释longnon coding rna名词解释 Long noncoding RNA(LncRNA)是一类长度大于200个核苷酸的长链非编码RNA。它属于非编码基因组的重要组成部分,一些LncRNA的长度甚至超过90kb,被称为macroRNA。研究表明,LncRNA在剂量补偿效应、表观遗传调控、细胞周期调控和细胞分化调控等众多生命活动中发挥重要作用...
lncRNA【Long Noncoding RNA】即长非编码RNA。作为不编码蛋白质的DNA,这部分DNA曾经一度被人们认为是“垃圾DNA”,它的转录产物被称为“转录噪声”。经研究发现这其中有些RNA虽然不直接参与基因编码和蛋白质合成,但是在基因转录后【调控】、【剪切】和【修饰】具有十分重要的功能。【那么判断一个lncRNA是否是转录...
Long Non-Coding RNA refers to a type of RNA molecule that is longer than 200 nucleotides and does not have the ability to encode proteins. These RNA molecules are classified as non-coding genes and play a role in various cellular processes. ...
The invention provides a new long noncoding RNA (LncRNA) Lnc21q22.11 sequence, and a primer pair and kit for detecting expression level of the long noncoding RNA in cells and tissues. The full length of the LncRNA Lnc21q22.11 is identified to be 1202bp for the first time, the ...
我们鉴定了外泌体长非编码RNA(lncRNA),称为淋巴结转移相关的转录子2(LNMAT2),在体外刺激了HLEC管的形成和迁移,并在体内增强了肿瘤的淋巴管生成和淋巴结转移。在机制上,LNMAT2通过与异质核糖核蛋白A2B1(HRNPA2B1)直接相互作用,将LNMAT2负载到BCa细胞分泌的外泌体上。随后,外泌体LNMAT2被HLECs内化,表观...
database31were excluded; (7) Intersection of the transcripts filtered by CPC, Pfam, and SwissProt were assigned as potential lncRNAs. Various kinds of lncRNAs (i.e., lincRNAs (Long intergenic non-coding RNA), intronic lncRNAs, anti-sense lncRNAs, and sense lncRNAs) were nominated by ...
Rinn, J. L.et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell.129, 1311–1323 (2007). ArticlePubMed Wang, B.et al. Overexpression of long non-coding RNA HOTAIR promotes tumor growth and metastasis in human osteosarcoma.Mol Cells....
长链非编码RNA(long noncoding RNA, lncRNA)指的是长度超过200nt的RNA分子。它们不编码蛋白,位于细胞核或胞质内,具有保守的二级结构,可与蛋白质、DNA和RNA相互作用,通过多种机制(如基因印记、染色质重塑、细胞周期调控、剪接调控、mRNA降解和翻译调控等)在多种层面上(如表观遗传学、转录调控及转录后调控等)调控基...
Longnoncoding RNAis a class of RNA discovered to be important in brain development and neurodevelopmental regulation [37]. Similar tomiRNA, there are several under types of lncRNA grouped by structure and their genomic location, including antisense-, sense-, intronic-, bidirectional-, and intergeni...
2013 long noncoding rna is prognostic marker for esophageal squamous cell carcinoma progreplosone长链非编码RNAhotair食管鳞状细胞癌进展生存预后标志物.pdf,Long Noncoding RNA HOTAIR Is a Prognostic Marker for Esophageal Squamous Cell Carcinoma Progression a