Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs into their acyl-CoA derivatives. Purified ACSL4 is an arachidonic acid (20:4)-preferring ACSL isoform, and ACSL4 is therefore a probable regulator of lipid mediator production in intact cells. Eicosanoids ...
In Arabidopsis thaliana, LONG-CHAIN ACYL-COA SYNTHETASEs (LACSs) catalyze the synthesis of long-chain acyl-CoAs and function in diverse biological processes. We have recently revealed that LACS2 is primarily involved in the production of polyunsaturated linolenoyl-CoA, essential for the activation ...
Fatty acids (FAs) must be esterified by fatty acyl-CoA synthetases to form biologically active acyl-CoA in order to enter the anabolic and/or catabolic pathway. Long-chain acyl-CoA synthetase 4 (ACSL4) is associated with female reproduction. However, whether it is involved in decidualization ...
Distinct long chain and very long chain fatty acyl CoA synthetases in rat liver peroxisomes and microsomes Mitochondria, peroxisomes, and microsomes were isolated from rat liver homogenates, and stearic acid and lignoceric acid 尾-oxidation, as well as stearoyl CoA synthetase and lignoceroyl CoA synt...
Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five me... Mashek, Douglas G.,...
Of relevance, the family of long-chain acyl-CoA synthetases catalyze the addition of a coenzyme-A group to fatty acids (FA) within cells and have been hypothesized to direct FA to distinct fates within cells. Long-chain acyl-CoA synthetase-4 (ACSL4) preferentially activates arachidonic acid (...
Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiot... 2001. Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and ...
Long chain fatty acid synthetases (LACSs) activate the fatty acid chains produced by plastidial de novo biosynthesis to generate acyl‐CoA derivatives, important intermediates in lipid metabolism. Oilseeds, like sunflower, accumulate high levels of triacylglycerolsintheirseedstonourishtheembryoduringgerminat...
Of particular interest, long-chain acyl-CoA synthetases (ACSL) catalyze the addition of a coenzyme-A group to fatty acids (FA) within cells and have been hypothesized to direct FA to distinct fates within cells. Intriguingly, the ACSL4 isoform is suggested to preferentially activate ...
In contrast, the long-chain acyl-CoA synthetases (ACS) that catalyze the synthesis of acyl-CoA, the substrates for both synthetic and oxidative pathways, have been largely ignored. Absence of change in ACS activity under different physiologic conditions suggested that ACS played no role in the ...