Mitoplasts were able to oxidise palmitoylCoA in the presence of carnitine and added outer-membrane fraction had no effect on this oxidation. It was concluded that a long-chain acylCoA synthetase (EC 6.2.1.3) was located on the outer membrane and that the activity of this enzyme in assays ...
1. 1. The microsomal long-chain acyl-CoA synthetase (acid: CoA ligase (AMP), EC 6.2.1.3) from rat liver was stimulated by high concentrations of salts. 2. 2. This stimulation has been compared with the stimulation obtained with the protein factor present in particle-free supernatant 1. Bo...
Key words: Long-chain acyl-CoA synthetase; Fatty acid; Proliferation; Apoptosis; Liver diseases; Metabolic diseases; Pathways © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. Core tip: Recent research has shown that long- chain acyl-CoA synthetase (...
因此脂酰辅酶A合成酶在脂肪酸合成与分解代谢中起着关键作用,属于多基因家族编码的酶,至少由25个成员组成( J i a等,2007) ,根据催化脂肪酸的碳链长度的特异性可分为超长链脂酰CoA合成酶( VACSL,又称FATP) 、长链脂酰CoA合成酶(10ng—chai n acyl - CoA synthetase,ACSL) 和中链脂酰CoA合成酶( M ACSL...
1. 1. The activities of long-chain acyl-CoA synthetase (acid : CoA ligase (AMP-forming), EC 6.2.1.3) and the ‘outer’ carnitine long-chain acyltransferase (palmitoyl-CoA: l-carnitine O-palmitoyltransferase, EC 2.3.1.21) have been estimated in intact brown adipose tissue mitochondria. The ...
The presence of much greater hexacosanoyl CoA synthetase activity in the purified preparations of microsomes and peroxisomes compared to mitochondria, suggests that the synthesis of coenzyme A derivatives of very long chain fatty acids (... H, Singh,N, Derwas,A, Poulos - 《Archives of Biochemist...
Rodgers JB, Tanson R, Fromm H: Acyl CoA synthetase for long chain fatty acid in rat small bowel and the influence of diets containing different compositions of fatty acids on in- testinal lipid-reesterifying enzymes activities. Biochem Biophys Acta 270:453-462, 1976...
[40] Long-chain acyl-CoA synthetase from rat liver: EC 6.2.1.3 acid:CoA ligase (AMP-forming)doi:10.1016/0076-6879(81)71042-5Takao TanakaKohei HosakaShosaku NumaMethods in Enzymology
Long chain acyl-CoA synthetase (ACSL; fatty acid CoA ligase: AMP forming; EC 6.2.1.3) catalyzes the formation of acyl-CoA through a process, which requires fatty acid, ATP and coenzymeA as substrates. In the yeast Saccharomyces cerevisiae the principal ACSL is Faa1p (encoded by the FAA1 ...
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