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Long-chain acyl-CoA synthetase 1 (ACSL1) converts free fatty acids into acyl-CoAs. Mouse studies have revealed that ACSL1 channels acyl-CoAs to 尾-oxidation, thereby reducing glucose utilization, and is required for diabetes-accelerated atherosclerosis. The role of ACSL1 in humans is unknown....
Long-chain acyl-coenzyme A synthetase 1 (LACS1)Lipid metabolismSaccharomyces cerevisiaeAfrican oil palm ( Elaeis guineensis Jacq.) is the highest-yielding oil crop in the world. Recent studies have shown the importance of long-chain acyl-CoA synthetases (LACSs) in lipid biosynthesis and ...
long-chainacyl-coasynthetaseinfattyacidmetabolisminvolvedliverand 系统标签: acylfattysynthetasecoadiseasesmetabolism SubmitaManuscript:http://.wjgnet/esps/ HelpDesk:http://.wjgnet/esps/helpdesk.aspx DOI:10.3748/wjg.v21.i12.3492 WorldJGastroenterol2015March28;21(12):3492-3498 ISSN1007-9327(print)IS...
Long chain acyl-CoA synthetase (ACSL; fatty acid CoA ligase: AMP forming; EC 6.2.1.3) catalyzes the formation of acyl-CoA through a process, which requires fatty acid, ATP and coenzymeA as substrates. In the yeast Saccharomyces cerevisiae the principal ACSL is Faa1p (encoded by the FAA1 ...
A complementary DNA clone encoding the entire human long-chain acyl-CoA synthetase was isolated and the total 698-amino acid sequence was deduced. The amino acid sequence of human long-chain acyl-CoA synthetase shows 84.9% identity to that of rat long-chain acyl-CoA synthetase. The nucleotide ...
Because the signaling eicosanoids, epoxyeicosatrienoic acids (EETs) and HETEs, are esterified to membrane phospholipids, we asked which long-chain acyl-CoA synthetase (ACSL) isoforms would activate these molecules and whether the apparent FA substrate preferences of each ACSL isoform might differ dependi...
1. 1. The activities of long-chain acyl-CoA synthetase (acid : CoA ligase (AMP-forming), EC 6.2.1.3) and the ‘outer’ carnitine long-chain acyltransferase (palmitoyl-CoA: l-carnitine O-palmitoyltransferase, EC 2.3.1.21) have been estimated in intact brown adipose tissue mitochondria. The ...
A complementary DNA clone encoding the entire human long-chain acyl-CoA synthetase was isolated and the total 698-amino acid sequence was deduced. The amino acid sequence of human long-chain acyl-CoA synthetase shows 84.9% identity to that of rat long-chain acyl-CoA synthetase. The nucleotide ...
The presence of much greater hexacosanoyl CoA synthetase activity in the purified preparations of microsomes and peroxisomes compared to mitochondria, suggests that the synthesis of coenzyme A derivatives of very long chain fatty acids (... H, Singh,N, Derwas,A, Poulos - 《Archives of Biochemist...