Long-chain acyl-CoA synthetases and fatty acid channeling. Future Lipidol. 2007; 2 :465–476. doi: 10.2217/17460875.2.4.465. [ Cross Ref ]Mashek D. G., Li L. O., Coleman R. A. Long-chain acyl-CoA synthetases and fatty acid channeling. Future Lipidology . 2007; 2 (4):465–476. ...
AMP is then exchanged with CoA to produce the activated acyl-CoA. The release of AMP in this reaction defines the superfamily of AMP-forming enzymes. The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS). On ...
Presents information on the role of long-chain acyl-CoA synthetases (ACS) in channeling fatty acids toward complex lipid synthesis and storage or toward oxidation. Molecular characterization of rat ACS; Evidence for independent functions of ACS isoforms; Relationship between Acyl CoA partitioning and in...
Incorporation of free 20:4 into phospholipids requires thioesterification of free 20:4 by enzymes belonging to the group of long-chain acyl-CoA synthetases. These enzymes produce acyl-CoAs from FAs >12 carbons in length. There are five long-chain acyl-CoA synthetase (ACSL) isoforms in humans...
Acyl-CoA synthetases long-chain (ACSLs) are a family of enzymes responsible for converting free long-chain FAs into fatty acyl-CoA esters, which is the prerequisite step for FAO. In turn, fatty acyl-CoAs can be transported into the mitochondrial matrix and undergo FAO [23]. The five ectopi...
Studies have been made on the subcellular localization of two long-chain acyl-coenzyme-A synthetases as well as glycerolphosphate acyltransferase and the acyl-CoA-oxidizing system in Candida lipolytica grown on oleic acid. Acyl-CoA synthetase I is distributed among different subcellular fractions, inclu...
The primary sequence of the murine fatty acid transport protein (FATP1) is very similar to the multigene family of very long chain (C20-C26) acyl-CoA synthetases. To determine if FATP1 is a long chain acyl coenzyme A synthetase, FATP1-Myc/His fusion protein was expressed in COS1 cells,...
2,4-Dienoyl-CoA reductase FadL: Long-chain fatty acid transport protein Fas: Fatty acid synthase (bacteria type) NMS: Neonatal maternal separation PCoA: Principal coordinate analysis SLCFAs: Saturated long-chain fatty acids TesA: Acyl-CoA thioesterase I ...
Long-chain fatty acyl-CoAs are synthesized by the long-chain acyl-CoA synthetase (or ligase) isoforms. These isoforms are regulated independently and have different tissue expression patterns and subcellular locations. All the isozymes of this family, although differing in substrate specificity...
2,4-Dienoyl-CoA reductase FadL: Long-chain fatty acid transport protein Fas: Fatty acid synthase (bacteria type) NMS: Neonatal maternal separation PCoA: Principal coordinate analysis SLCFAs: Saturated long-chain fatty acids TesA: Acyl-CoA thioesterase I ...