The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS). On this basis, five sub-families of ACS have been characterized. The purpose of this review is to report on the large family of mammalian long-chain acyl...
long-chain acyl-coenzyme A synthetaselipidosinscFat2pBy consensus, the acyl-CoA synthetase (ACS) community, with the advice of the human and mouse genome nomenclature committees, has revised the nomenclature for the mammalian long-chain acyl-CoA synthetases. ACS is the family root name, and the...
Bioactive N -acylethanolamines (NAEs) are ethanolamides of long-chain fatty acids, including palmitoylethanolamide, oleoylethanolamide and anandamide. In animal tissues, NAEs are biosynthesized from membrane phospholipids. The classical "transacylation-phosphodiesterase" pathway proceeds via N -acyl-ph...
The BCKDH complex is inhibited by NAD(H) and branched-chain-acyl-CoA (90). BCAAs bypass the liver, owing to lack of mitochondrial branched-chain aminotransferase (BCATm) in this tissue. This allows leucine to be a more powerful activator of mTORC1 (mechanistic target of rapamycin complex ...
Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. Biochem Biophys Res Commun. 442: 195- 201.Ohkuni, A.; Ohno, Y.; Kihara, A. Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. Biochem...