内容提示: 中文科技期刊数据库(全文版)医药卫生 101 炎症微环境下 LncRNA ANCR 调控 hBMSCs 成骨分化的机制 王旭华 陈兆元 周华强 罗嘉全(通讯作者) 赣南医学院第一附属医院骨科,江西 赣州 341000 摘要 :目的:探讨炎症微环境下 LncRNA ANCR 对 hBMSCs 成骨分化的影响及可能机制。方法:密度梯度分离法分离并培养...
在本实验室之前的研究中,我们发现lncRNA ANCR参与TGF-β1诱导的EMT过程。在TGF-β1诱导乳腺癌细胞发生EMT的过程中,TGF-β1通过降低了ANCR启动子的H3和H4乙酰化水平,使得ANCR的表达受到抑制。但是ANCR在TGF-β1诱导的EMT过程中都起到了哪些作用,以及ANCR是通过何种机制发挥功能还尚不清楚。本研究发现,ANCR作为一...
本研究发现LncRNA-ANCR在胃组织中有较高的表达,且高表达ANCR的患者具有较高TNM分期及较低的细胞分化程度,表明LncRNA-ANCR与GC进展程度及分子分型密切相关。为了深入探明LncRNA-ANCR对GC细胞的行为影响,在HGC-27细胞中引入ANCR cDNA全长...
The apoptosis, transwell invasion, migration, colony formation, and proliferation assays were conducted to evaluate the influences of lncRNA ANCR depletion, EZH2 reduction, or PTEN elevation on the cell biology of glioma cells. The relationships between ANCR and EZH2, and between EZH2 and PTEN were...
LncRNA ANCRheterogeneous nuclear ribonucleoprotein A1ubiquitinationmiR-140-3phepatocellular carcinomametastasisLncRNA ANCR plays important roles in the modulation of epithelial mesenchymal transition (EMT) and tumour metastasis in many tumours. However, the role of ANCR in regulating hepatocellular carcinoma (...
LncRNA ANCR调控miR-331表达影响胃癌细胞的生物学行为 刘玉华1,魏蔚1,崔淑萍2 1.平顶山学院医学院,河南 平顶山 467000; 2.河南省肿瘤医院胸外科,河南 郑州 450008 胃癌是导致癌症死亡的第二大原因[1],是东亚、东欧及中南美洲部分地区...
LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression Zhao-Yang Yang,Fang Yang,Ying-Li Zhang,Bao Liu,Meng Wang,Xuan Hong,Yan Yu ,Yao-Hui Zhou,Hai Zeng #1Indigofera tanganyikensiscomment accepted December 2019...
欢迎访问《中国癌症杂志》官方网站,今天是2025年3月7日 星期五分享: LncRNA ANCR调控miR-331表达影响胃癌细胞的生物学行为 刘玉华,魏蔚,崔淑萍 LncRNA ANCR regulates the biological behavior of gastric cancer cells through miR-331 expression LIU Yuhua, WEI Wei, CUI Shuping ...
Methods The lncRNA ANCR siRNA lentiviral vector and the lentiviral empty vector were respectively transfected into adipose-derived stem cells, which were divided into siRNA group, empty vector group, and stem cell group. Observe ALP staining effect by alkal...
ANCR主要定位在细胞质中.生物信息学预测和双荧光素酶报告基因实验证实ANCR与miRNA-101-5P,miRNA-101-5P与IL6ST均有靶向作用.在炎症微环境下,过表达miRNA-101-5p具有促进hBMSCs成骨分化的作用.结论:炎症微环境下hBMSCs成骨分化过程中LncRNA ANCR表达升高,LncRNA ANCR充当miR-101-5P的海绵调控IL6ST,影响人骨髓间...