结果发现,小鼠乳腺上皮细胞中LINK-A的增加通过与HFD诱导的HB-EGF协同作用来稳定HIF1α,HIF1α作为一种转录因子调节炎症因子IL-1β和CXCL16的表达和释放,从而触发脂肪组织微环境中的炎症信号。此外,这种细胞因子诱导的微环境重塑通过LINK-A激活的HB-EGF/HIF1α环继续进行,导致脂肪组织功能障碍和适应性产热功能受损,...
The LINK-A lncRNA activates normoxic HIF1alpha signalling in triple-negative breast cancer. Nat Cell Biol. 2016;18:213-24.Lin A, Li C, Xing Z, et al. The LINK-A lncRNA activates normoxic HIF1伪 signalling in triple-negative breast cancer[J]. Nature Cell Biol, 2016, 18(2): 213-...
Furthermore, meta-analysis showed the correlation betweenLINK-Aexpression and incidence of a SNP (rs12095274: A>G), AKT phosphorylation status, and poor outcomes for breast and lung cancer patients. PIP3-binding lncRNA modulates AKT activation with broad clinical implications. 展开 ...
Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role i
Long intergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR) is a long non-coding RNA (lncRNA) which is induced in hepatocellular carcinoma. Its depletion invokes a proliferation defect, triggers senescence and inhibits colony formation in li
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeeding,...
leads to information loss. Such a problem largely results in low accuracy. In the pipeline of our proposed method, the integrated network completely relies on the network profile, which indicates its general application in many link prediction problems. The limited data of the interaction profile ...
Dominance hierarchy is a fundamental phenomenon in grouped animals and human beings, however, the underlying regulatory mechanisms remain elusive. Here, we report that an antisense long non-coding RNA (lncRNA) of synapsin II, named as AtLAS, plays a cruc
a competitive endogenous RNA (ceRNA) that regulates cellular biological behavior by competitively binding to miR-106a-5p with REEP5. In conclusion, our results show that MALAT1 could function as ceRNA promote the proliferation, invasion and metastasis of TNBC cells through MALAT1/miR-106a-5p/...
Metastasis is a well-known poor prognostic factor in cancer. However, the mechanisms how long non-coding RNAs (lncRNAs) regulate metastasis in colorectal cancer (CRC) remain largely unknown. Besides, tumor-associated macrophages (TAMs) play an important