近日,Advanced Science期刊(IF15.1)发表了一篇题为LncRNA LINK-A Remodels Tissue Inflammatory Microenvironments to Promote Obesity的研究论文。该研究报道了一个与肥胖相关的人类lncRNA LINK-A,作为连接体内代谢微环境和能量消耗的关键分子。揭示了其通过LINK-A/HB-EGF/HIF1α反馈环轴以自放大方式诱导炎症因子IL-1...
随后,为了进一步识别FTO调控的lncRNA,研究者在两个食管鳞癌细胞系中沉默和过表达FTO,然后测量了14个注释的ncRNA的表达水平,这些ncRNA先前在化疗耐药的食管鳞癌细胞系中显著高于相应的亲本细胞系4个ncRNA(TTLL3、LINC00663、PRSS30P、CETN4P)的表达低于实时荧光定量pcr的检测限。在其余的10个ncRNA中,只有LINK-A在KYSE...
The LINK-A ln- cRNA activates normoxic HIF1alpha signalling in triple-negative breast cancer. Nat Cell Biol 2016; 18: 213-224.Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, et al. 2016 The LINK-A lncRNA activates ...
Furthermore, meta-analysis showed the correlation betweenLINK-Aexpression and incidence of a SNP (rs12095274: A>G), AKT phosphorylation status, and poor outcomes for breast and lung cancer patients. PIP3-binding lncRNA modulates AKT activation with broad clinical implications. 展开 ...
LINKA lncRNA functions in the metastasis of osteosarcoma by upregulating HIF1αdoi:10.3892/ol.2019.10177Boming ZhaoKebin LiuLin CaiOncology Letters
下面是其中5个非编码RNA的例子,科学家认为它们参与了人类身体中的许多活动,这当中既有好的,也有坏的。 1. lncRNA - 癌症疗法的克星 有时候,研究人员无法理解一些抗癌药物为什么会失效。例如,化疗药物阿糖胞苷通常是医生开给急性骨髓性白血病(AML)患者的第一药物,但最终对于30%到50%的AML患者,这种药物都会失效。
Another way for lncRNAs to regulate cMYC activity is to affect its localization. In lung adenocarcinoma,PD-L1gene can generate a lncRNA (PD-L1-lnc) by alternative splicing that supports cancer aggressiveness by binding to the cMYC/MAX complex and aiding its translocation to the nucleus [89]....
近日,来自德国马克斯·普朗克分子遗传学研究所的Stefan Mundlos团队在Nature杂志发表题为Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator的文章,通过人和小鼠的实验表明,在人类2号染色体上存在一个lncRNA位点——Maenli,其缺失导致严重的先天性肢体畸形。机制上,Maenli的转录活性顺式作用调...
lncRNAs in the cytoplasm regulate mRNA stability by directly controlling de-adenylation, as well as protecting mRNA transcripts from miRNA mediated degradation by acting as molecular decoys, a process known as miRNA sponging [41,42]. A novel example of this mechanism is lncRNA SNHG7 which promote...
LncRNA, as a main type of competing endogenous RNAs (ceRNAs), can function as miRNA sponges having a lower regulatory effect of miRNA on mRNAs, i.e., miRNAs have an important influence in the molecular mechanisms of lncRNAs [1]. Previous works of human lncRNA function annotation were ...