从TCGA数据库中的TCGA-COAD数据集获得了lncRNA GAS6-AS1表达数据和相应的临床信息,包括41例正常结肠组织和446例结肠癌组织,样本信息包括性别、年龄、T分期、N分期、M分期、临床分期和微卫星不稳定性(MSI)状态(MSH:高度微卫星不稳...
lncRNA GAS6-AS1靶向调控IL-11对子宫 内膜基质细胞向成纤维细胞分化的影响doi:10.3969/j.isnn.1002-266X.2023.13.003巫剑红代荫梅田玉翠蒋子雯王静璇张宇迪Shandong Medical Journal
The aim of this study was to uncover the role of GAS6-AS1 in the regulation of progression and glucose metabolism in LUAD. We discovered that overexpression of GAS6-AS1 suppressed tumor progression of LUAD both in vitro and in vivo. Metabolism-related assays revealed that GAS6-AS1 inhibited...
怀疑 lncRNA GAS6-AS1 可能通过与转录因子 E2F1 相互作用来调节 GLUT1 的表达。RIP结果表明 E2F1 募集了GAS6-AS1 的 RNA 片段(图 4C)。蛋白质印迹分析显示 E2F1 蛋白特异性结合 GAS6-AS1 的有义序列,但不结合反义对照(图 4D-E)。在 GAS6-AS1 过表达后,E2F1 的 mRNA 和蛋白质表达没有改变(图 4F-G)...
EGFR-AS1,EGOT,EMX2OS,EPB41L4A-AS2,FAM212B-AS1,FAM215A,FAS-AS1,FENDRR,FEZF1-AS1,FGF14-AS2, FOXC2-AS1,FOXD2-AS1,FOXD3-AS1,FTX,GAPLINC,GAS5,GAS5-AS1,GAS6-AS1,H19,HAND2-AS1,HAR1A,HCP5,HEIH,HIF1A-AS1,HNF1A-AS1,HOTAIR, HOTAIRM1,HOTTIP,HOXA-AS3,HOXB-AS3,HULC,IGF2-AS,IPW...
LncRNA在肺癌中的研究进展 Advances in Clinical Medicine 临床医学进展, 2018, 8(10), 915-921 Published Online December 2018 in Hans. http://www.hanspub.org/journal/acm https://doi.org/10.12677/acm.2018.810152 文章引用: 李浩然, 李泽环, 高健, 丁建勇. LncRNA 在肺癌中的研究进展[J]. 临床...
SWINGN enhancer locus controls GAS6 expression The observation that the majority of SMARCB1-associated lncRNAs are transcribed from regions of active chromatin bound by SMARCB1 itself, prompted us to investigate with more detail the regulation of one of these loci. In particular, we focused our atte...
Notably, a common type of cancer-related lncRNA is the antisense partner of a protein-coding gene, such as HNF1A-AS1 [14] and GAS6-AS1 [15]. As previously reported, ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2) has been identified as...
GAS6-AS2 Up miR-298/CDK9 Proliferation↑, cell cycle↑, EMT↑, metastasis↑ [134] ARAP1-AS1 Up miR-4735–3p/NOTCH2 Proliferation↑, invasion↑, migration↑ [135] PlncRNA-1 Up miR-136/smad3 Proliferation↑, invasion↑, migration↑ [136] CALML3-AS1 Up miR-4316/ZBTB2 Proliferation↑,...
Non-Small Cell Lung Cancer: BANCR, CCAT2, GAS6-AS1, HOTAIR, MALAT1, MEG3. Other Lung Cancers: ACTA2-AS1, LUCAT1. Melanoma: BANCR, HOTAIR, PTENP1. Multiple Myeloma: MEG3, PVT1. Nasopharyngeal Carcinoma: HOTAIR, LINC00312. Neuroblastoma: HAND2-AS1, SNHG16. Oesophageal Squamo...