This study plans to investigate the effects of long-noncoding RNA MACC1-AS1 on glioma cells and its mechanism at metabolic plasticity angle. The MACC1-AS1 level was identified both in glioma tissues and in cells. Then the effects of MACC1-AS1 abnormal level on cell viability, apoptosis, ...
Long noncoding RNA (lncRNA) represents a class of endogenous RNAs that regulate gene expression in eukaryotes. To date, the function and underlying mechanism of the majority of mammalian lncRNAs remain unknown. Here, we report that MACC1-AS1, a cognate a
另一方面,ZHAO等发现,lncRNA-结肠癌转移相关基因1(MACC1)-AS1在胃癌组织中表达显著升高。在代谢应激状态下,lncRNA-MACC1-AS1升高,并稳定了MACC1mRNA,使MACC1转录增强,通过AMPK/Lin28途径协调,促进代谢可塑性,促进胃癌细胞增殖并抑制细胞凋亡。再者,LIU等发现,lncRNA-BC005927在胃癌样品中表达上调。在缺氧条件下,...
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1. Mol Cancer. 2018;17:69. Article PubMed PubMed Central Google Scholar Wu Q, Xiang S, Ma J, Hui P, Wang T, Meng W, et al. Long non-coding RNA CASC15 regulates ...
Two lncRNAs, MACC1-AS1 and UCA1, co-mediate the expression of multiple mRNAs through interaction with individual miRNAs in breast cancer cells 2022, Non-coding RNA Research Citation Excerpt : LncRNAs basically consist of at least 200 nucleotides and have limited protein-coding potential. Currently,...
25 MACC1-AS1 is involved in gastric cancer cell metabolic plasticity by promoting stability of MACC1 mRNA through the direct binding mode.26 The subcellular distribution based on IGF2 AS provides a prerequisite for its function mechanisms (Figures 5A–5C). In the nucleus, we had demonstrated ...
在代谢应激状态下,lncRNA-MACC1-AS1升高,并稳定了MACC1mRNA,使MACC1转录增强,通过AMPK/Lin28途径协调,促进代谢可塑性,促进胃癌细胞增殖并抑制细胞凋亡。再者,LIU等发现,lncRNA-BC005927在胃癌样品中表达上调。在缺氧条件下,缺氧诱导因子-1α(HIF-1α)能调控lncRNA-BC005927表达升高,导致转移相关基因表达升高,...
7SK, AA174084, AB073614, ABHD11-AS1, ACTA2-AS1, ADAMTS9-AS2, AF339813, AFAP1-AS1, AIRN-1, AIRN-2, AK095147, AP5M1, APOC1P1, ARA-1, ARA-2, ATG9B-1, ATG9B-2, BANCR, BCAR4-1, BCAR4-2, BGLT3, BLACAT1, BOK-AS1, C5orf66-AS1, CASC11-1, CASC11-2, CASC2-1, ...
Three lncRNAs (XIST, TUG1, GABPB1-AS1) could possibly be selected as key lncRNAs which may play an important role in the development of CN-AML. Particularly, GABPB1-AS1 was highly expressed in CN-AML by both bioinformatic analysis and experimental verification in AML cell line (THP-1) ...
Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer Mol. Oncol., 13 (5) (2019), pp. 1268-1279 Google Scholar [72] H.C. Chung, W. Ros, J.P. Delord, R. Perets, A. Italiano, R. Shapira-Frommer, L. Manzuk, S.A. Piha-Paul, L. Xu, S. Zeigenfuss...