Additionally, overexpression of MACC1-AS1 in pancreatic cancer cells was found to enhance tolerance to gemcitabine and suppress ferroptosis. Proteomic analysis of drug-resistant pancreatic cells revealed that overexpressed MACC1-AS1 inhibited the ubiquitination degradation of residues in the protein kinase ...
Long noncoding RNA (lncRNA) represents a class of endogenous RNAs that regulate gene expression in eukaryotes. To date, the function and underlying mechanism of the majority of mammalian lncRNAs remain unknown. Here, we report that MACC1-AS1, a cognate a
Also, DDX11-AS1 knockdown reduced HCC tumor growth in vivo. Besides, DDX11-AS1 could interact with miR-195-5p, and miR-195-5p inhibitor reversed the inhibitory effect of silenced DDX11-AS1 on HCC cell progression. In addition, MACC1 was a target of miR-195-5p, and its overexpression ...
In GC, lncRNA MACC1-AS1 is induced by transforming growth factor β1 (TGF-β1) secreted by mesenchymal stem cells (MSCs), which suppresses the expression of miR-145-5p (the stemness & chemoresistance inhibitor) to accelerate FAO-dependent (fatty acid oxidation) stemness and chemotherapeutic ...
The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1. Mol Cancer. 2018;17:69. Article PubMed PubMed Central Google Scholar Wu Q, Xiang S, Ma J, Hui P, Wang T, Meng W, et al. Long non-coding RNA CASC15 regulates ...
Conclusion: Our data revealed that DDX11-AS1 could act as an oncogenic regulator in HCC, providing a potential therapeutic target for HCC treatment. 展开 关键词: DDX11-AS1 HCC MACC1 Progression miR-195-5p DOI: 10.1016/j.aohep.2020.09.003 ...
MACROD2-AS1-1, MACROD2-AS1-2, MEG3-1, MEG3-2, MER11C, MIAT, MINA, MIR100HG, MIR155HG, MIR17HG, MIR31HG, MT1JP, MYCNOS-1, MYCNOS-2, MYCNUT, NAMA-1, NAMA-2, NBAT-1, NDM29, NEAT1-1, NEAT1-2, NKILA, NPTN-IT1, OR3A4P, ORAOV1, PACERR, PANDAR, PARROT, PAX8-AS...
Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer Mol. Oncol., 13 (5) (2019), pp. 1268-1279 CrossrefView in ScopusGoogle Scholar [72] H.C. Chung, W. Ros, J.P. Delord, R. Perets, A. Italiano, R. Shapira-Frommer, L. Manzuk, S.A. Piha-Paul, L...
Malignant tumors have become the most dangerous disease in recent years. Chemotherapy is the most effective treatment for this disease; however, the proble
Three lncRNAs (XIST, TUG1, GABPB1-AS1) could possibly be selected as key lncRNAs which may play an important role in the development of CN-AML. Particularly, GABPB1-AS1 was highly expressed in CN-AML by both bioinformatic analysis and experimental verification in AML cell line (THP-1) ...