EdU实验表明,GAS6-AS1过表达后HT29细胞活力显著增加(图2F),而GAS6-AS1敲低后LoVo细胞活力显著下降(图2G)。为了进一步揭示GAS6-AS1在CRC细胞迁移中的功能,研究者进行了划痕和transwell实验。在划痕实验中,研究者发现GAS6-AS1上调...
Besides, GAS6-AS1 activated the PI3K/AKT pathway by targeting the miR-3243p/SETD1A axis. Rescue assays showed that SETD1A overexpression or 740Y-P treatment reversed the inhibitory effect of silenced GAS6-AS1 on cellular progresses of breast cancer. In summary, this work first explored the ...
之前的分析表明 GAS6-AS1 可能参与了“转录调控,DNA 模板化”的生物过程(图 2A)。通过对泛癌中的 LncRNA Modulator Atlas (LncMAP)数据集的搜索,一组转录因子预测与 GAS6-AS1 相互作用(图 4B)。怀疑 lncRNA GAS6-AS1 可能通过与转录因子 E2F1 相互作用来调节 GLUT1 的表达。RIP结果表明 E2F1 募集了GAS6-...
SWINGN enhancer locus controls GAS6 expression The observation that the majority of SMARCB1-associated lncRNAs are transcribed from regions of active chromatin bound by SMARCB1 itself, prompted us to investigate with more detail the regulation of one of these loci. In particular, we focused our atte...
EGFR-AS1,EGOT,EMX2OS,EPB41L4A-AS2,FAM212B-AS1,FAM215A,FAS-AS1,FENDRR,FEZF1-AS1,FGF14-AS2, FOXC2-AS1,FOXD2-AS1,FOXD3-AS1,FTX,GAPLINC,GAS5,GAS5-AS1,GAS6-AS1,H19,HAND2-AS1,HAR1A,HCP5,HEIH,HIF1A-AS1,HNF1A-AS1,HOTAIR, HOTAIRM1,HOTTIP,HOXA-AS3,HOXB-AS3,HULC,IGF2-AS,IPW...
Notably, a common type of cancer-related lncRNA is the antisense partner of a protein-coding gene, such as HNF1A-AS1 [14] and GAS6-AS1 [15]. As previously reported, ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2) has been identified as...
GAS6-AS2 Up miR-298/CDK9 Proliferation↑, cell cycle↑, EMT↑, metastasis↑ [134] ARAP1-AS1 Up miR-4735–3p/NOTCH2 Proliferation↑, invasion↑, migration↑ [135] PlncRNA-1 Up miR-136/smad3 Proliferation↑, invasion↑, migration↑ [136] CALML3-AS1 Up miR-4316/ZBTB2 Proliferation↑,...
Tumor Suppressor Genes: ADAMTS9-AS2, CAHM, DLEU2, DLX6-AS1, GACAT1, GAS5, GAS6-AS1, GNAS-AS1, LINC00261, LINC00312, MEG3, MIR31HG, MIR7-3HG, NAMA, NEAT1, PTCSC1, PTCSC3, PTENP1, TERC, TUSC7, WT1-AS, ZFAS1. Cancers: Bladder Cancer: BLACAT1, H19, MALAT1, MEG3, ...
LncRNA在肺癌中的研究进展 Advances in Clinical Medicine 临床医学进展, 2018, 8(10), 915-921 Published Online December 2018 in Hans. http://www.hanspub.org/journal/acm https://doi.org/10.12677/acm.2018.810152 文章引用: 李浩然, 李泽环, 高健, 丁建勇. LncRNA 在肺癌中的研究进展[J]. 临床...
Bladder Cancer: BLACAT1, H19, MALAT1, MEG3, SNHG16, TERC, TUG1, UCA1. Breast Cancer: BCAR4, GAS5, H19, HIF1A-AS2, HOTAIR, JADRR, LSINCT5, MIR31HG, MRPL23-AS1, TRERNA1, UCA1, XIST, ZFAS1. Cervical Cancer: MEG3. Colorectal Cancer: CCAT1, CCAT2, CRNDE, H19, HOT...