本研究以皮肤鳞癌细胞SCC13为研究对象,检测lncRNA LEF1-AS1、miR-612的表达,观察干扰lncRNA LEF1-AS1、miR-612的表达对其增殖、迁移、侵袭和凋亡的影响。 lncRNA LEF1-AS1通过靶向miR-612调控皮肤鳞状细胞癌细胞株增殖、凋亡、迁移侵...
PCR和双荧光素酶报告基因试验分析LEF1-AS1与miR-212-5p的靶向关系.结果显示,IL-1β处理显著增加软骨细胞的凋亡率(P<0.05),增加IL-6,TNF-α和IFN-γ的分泌量(P<0.05),上调LEF1-AS1表达(P=0.000),下调miR-212-5p表达(P=0.000).抑制LEF1-AS1表达或过表达miR-212-5p可降低IL-1β诱导的软骨细胞的凋亡率...
In addition, in HCC cells, lncRNA LEF1-AS1 binds miR-136-5p to remove the inhibition of miR-136-5p on WNK1 mRNA, thus promoting the expression of MMP9 and VEGF and stimulating the angiogenesis [37]. As a member of antiangiogenetic factor, THBS1 is one of the earliest identified ...
LncRNA LEF1-AS1 promotes osteogenic differentiation of dental pulp stem cells via sponging miR-24-3p[J]. Mol Cell Biochem, 2020, 475(1/2): 161-169. doi: 10.1007/s11010-020-03868-7. https://doi.org/10.1007/s11010-020-03868-7 https://doi.org/10.1007/s11010-020-03868-7 本文引用 ...
比较不同临床病理参数HSCC组织中LncRNA SNHG1、miR-143-3p表达的差异,分析LncRNA SNHG1与miR-143-3p表达的相关性以及LncRNA SNHG1、miR-143-3p表达与HSCC患者预后的关系。 结果HSCC组织中LncRNA SNHG1表达高于癌旁正常黏膜组织( P<0.05),miR-143-3p表达低于癌旁正常黏膜组织( P<0.05)。TNM分期Ⅲ期、...
MNX1-AS1 Cancer Oncogenic Biomarker 1. Introduction Cancers become a serious threat to human health since of its characteristic of concealment and recurrence [1], [2]. In 2020, there were 606,520 deaths and 18,065,090 new cancer cases in the United States, respectively [3]. Therefore, fin...
例如,lncRNA PRKCQ-AS1是IV网络中T细胞相关群落CM5的成员。 GSEA显示,在所有IV组中,CM5在第1天始终下调。与PRKCQ-AS1连接的基因的子集在第1天也被广泛下调。该子集的几个成员是众所周知的T细胞相关基因,例如CCR7,CD27,ITK,LEF1,THEMIS和SKAP1。这些发现表明PRKCQ-AS1可能与T细胞功能有关。使用YF-17D群组进行...
cells, in vitro and in vivo [99,108]. Suppression of LEF1-AS1 inhibits tumor growth, as well as liver and lung metastasis in vivo [100]. Mechanistically, STEAP3-AS1 drives colorectal cancer progression by regulating the STEAP3/GSK3β/Wnt/β-catenin axis [98]. Downregulation of STEAP3-...
AAJ, SISA, GMAA, AH, RJS, AK, ME, MTR, AS and AHZ wrote the main manuscript text and AH prepared figures 1-3. All authors reviewed the manuscript. Corresponding authors Correspondence toSaade Abdalkareem JasimorMamdouh Eldesoqui.
Article Open access 02 December 2020 LEF1-AS1 accelerates tumorigenesis in glioma by sponging miR-489-3p to enhance HIGD1A Article Open access 11 August 2020 Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression Article Open access 29 June 2023 Introduction...