LncRNA FGD5-AS1靶向miR -16-5p/CREB1轴减轻缺氧/复氧诱导大鼠H9c2心肌细胞凋亡的 机制研究 谢小芳,赵展庆,符妹垂 摘要 目的:探究长链非编码RNA (LncRNA )FGD5反义RNA1(FGD5- AS1)对缺氧/复氧(H/R )诱导的大鼠H9c2心肌细胞凋亡的影响以及对微小RNA -16-5p/cAMP 响应元件结合蛋白1(miR -16-5p/CREB1)...
LncRNA FGD5-AS1 has been studied as an oncogene in several cancers, however, the role it plays in oral squamous cell carcinoma (OSCC) still remain unclear. Methods: QRT-PCR was used to assess relevant RNAs expression. CCK-8 and colony formation were combined to investigate cell proliferation...
有实验表明,lncRNASGO1-AS1在体内外均能抑制胃癌细胞的侵袭和转移。SGO1-AS1通过竞争性结合多聚嘧啶区结合蛋白1(PTBP1)促进转化生长因子B1/2(TGFB1/2)mRNA的降解,导致转化生长因子β的产生减少,从而阻止上皮间充质转化和转移。Liu等发现,与正常胃癌细胞相比,l...
FGD5-AS1作为一种高表达丰度的lncRNA,在癌症中的非ceRNA生物学功能尚不清楚。 结果:作为细胞中最丰富的lncRNAs之一,FGD5-AS1已被证明可被ZEB1转录激活,因此与上皮-间充质转化(EMT)信号传导密切相关。临床分析表明,FGD5-AS1过表达在临床上与淋巴结转移相关,并预示GC患者生存期较差。功能缺失研究证实,FGD5-AS1敲低...
(P<0.05);ROC曲线显示,龈沟液lncRNA FAS-AS1,lncRNA FGD5-AS1水平诊断慢性牙周炎患者的曲线下面积(AUC)分别为0.914,0.890,联合诊断的AUC为0.950,较单一指标检测升高(P<0.05).结论慢性牙周炎患者龈沟液中lncRNA FAS-AS1,lncRNA FGD5-AS1表达均下降,二者联合检测对慢性牙周炎患者有一定诊断价值,并与病情程度及...
长链非编码RNA(LncRNA)是一种长度超过200个核苷酸而没有编码蛋白质能力的RNA.LncRNA FGD5-AS1在消化系统恶性肿瘤(胃癌,肝癌,结直肠癌,胰腺癌),呼吸系统恶性肿瘤(非小细胞肺癌)及乳腺和生殖系统恶性肿瘤(乳腺癌,宫颈癌,卵巢癌),头颈部恶性肿瘤(口腔鳞状细胞癌,喉鳞状细胞癌,甲状腺癌)及其他恶性肿瘤(胶质母细胞瘤...
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雌激素刺激实验表明,EPB41L4A - AS1 表达下降,PVT1 表达上升。ERα 基因敲低实验显示,PVT1 和 FGD5 - AS1 水平下降,而 EPB41L4A - AS1 不受影响。CARIP 联合 RT - qPCR 证实这 3 种 lncRNA 均与染色质相关。 基因沉默实验发现,敲低 3 种 lncRNA 会导致大量基因差异表达,部分差异表达基因与 ERα...
LncRNA FGD5-AS1 promotes the malignant phenotypes of ovarian cancer cells via targeting miR-142-5p. Apoptosis. 2021;26(5–6):348–60. Article PubMed Google Scholar Liu X, Ma J, Xu F, Li L. TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung ...
Long noncoding RNA FGD5-AS1 promotes colorectal cancer cell proliferation, migration, and invasion through upregulating CDCA7 via sponging miR-302e. Vitro Cell Dev Biol Anim. 2019;55:577–85. Article CAS Google Scholar Lu S, Zhang J, Lian X, Sun L, Meng K, Chen Y, Sun Z, Yin X,...