The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RN...
Owing to its high accuracy and specificity, scRNA-seq has become an ideal research tool for single cell study [29]. Unbiased high-throughput research can be performed with a minimum starting sample volume. ScRNA-seq can be used alongside multiomics to simultaneously analyse the genome, transcripto...
we addressed this limitation by describing the developmental trajectories of different cell types that make up the human liver at single-cell resolution. These transcriptomic analyses revealed that sequential cell-to-cell interactions direct functional maturation of hepatocytes, with non-parenchymal cells pl...
single-cell RNA sequencinghuman immunodeficiency virusIn Lusaka, Zambia, we introduced liver fine-needle aspiration biopsy (FNAB) into a research cohort of ... M Taonga,MS Wallace,P Hailey,... - 《Journal of Infectious Diseases》 被引量: 0发表: 2024年 Single-cell transcriptome analysis of agi...
空间分选可作为一种普遍适用的策略,结合高灵敏、高深度的单细胞蛋白质组学(single-cell proteomics),将为生物系统中细胞异质性研究、精细蛋白分子图谱构建、空间蛋白质网络分析等提供最本质的精准信息,为肿瘤异质性、干细胞分化、生殖细胞发育等提供新的思路和见解。
Here, we present a comprehensive view of the liver-stage transcriptomes of a human-infecting malaria parasite and its host cells at single-cell resolution. To achieve this goal, we coupled MPCC with Seq-Well, a recently developed low-cost and portable single-cell platform that does not require...
The human liver is an essential multifunctional organ. The incidence of liver diseases is rising and there are limited treatment options. However, the cellular composition of the liver remains poorly understood. Here we performed single-cell RNA sequencing of about 10,000 cells from normal liver ti...
Although the application of single-cell multi-omics in liver cancer research has been limited thus far, a revolution of individualised care for patients with HCC will only be possible by integrating various unimodal methods into multi-omics methodologies at the single-cell resolution. In this review...
Here, we dissect the diversity of LrICs by a comprehensive transcriptomic profiling using the unbiased single-cell RNA-sequencing (scRNA-seq). A total of 70, 706 of CD45immune cells from the paired liver perfusion, spleen and peripheral blood as references were profiled. We identified more ...
Cell Research, 2021年8月2日 8月2日,北京大学生命科学学院李程团队,与中国科学院动物研究所刘峰团队合作,在期刊 Cell Research 发表题为 Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics 的论文。北京大学生命科学学院石强博士,和中国科学院动物研究所博士研究...