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Wesley, B.T., Ross, A.D.B., Muraro, D.et al.Single-cell atlas of human liver development reveals pathways directing hepatic cell fates.Nat Cell Biol24, 1487–1498 (2022). https://doi.org/10.1038/s41556-022-00989-7 Download citation ...
Here, a single-cell transcriptome atlas of 171,814 NPCs from healthy and 5 typical liver disease mouse models, including alcoholic liver disease, nonalcoholic steatohepatitis (NASH), drug-induced liver injury, cholestatic, and ischemia-reperfusion liver injury is constructed. The inter- and intra-...
et al. Comprehensive integration of single-cell data. Cell 177, 1888–1902.e21 (2019). CAS PubMed PubMed Central Google Scholar Zhang, M. J., Pisco, A. O., Darmanis, S. & Zou, J. Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures. Elife 10, ...
The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RN...
Overall, we provide the first comprehensive single-cell atlas of mouse livers in response to TCS and delineate the key cellular and molecular processes involved in TCS-induced hepatotoxicity and fibrosis.Background Triclosan (TCS) is an antimicrobial agent that has been widely used worldwide for ...
berghei single-cell transcriptomes P. vivax cells were compared with a subset of the mouse Malaria Cell Atlas dataset (liver and blood asexual and sexual stages; https://zenodo.org/record/2843883#.Ygz7wC-l1bU) using the scmapCell() function in scmap (v 1.14.0) (Kiselev et al., 2018)...
This study first explored TME heterogeneity between primary lesions (PL) and LM to construct a comprehensive single-cell atlas of CRNELM patients, which was validated through multidimensional analyses, including spatial transcriptomics (ST), bulk RNA sequencing, and multiplex immunohistochemistry/immunofluore...
mesenchymal stem cellimmunomodulatorymass cytometryThe immunomodulatory effects of mesenchymal stem cells (MSCs) in acute liver injury involve coordination with the entire immune system. But mouse liver immune cdoi:10.2139/ssrn.3209537Jingqi LiuXiaotian Dong...
cell atlas in both healthy and diseased states is needed for new therapeutic target development and disease intervention improvement. With the development of high-throughput single-cell technology, we can now decipher heterogeneity, differentiation, and intercellular communication at the single-cell level ...