human cell atlasliver cancersingle cell RNAseqspatial transcriptomicstumor‐stroma interactionsMalignant cell growth is fueled by interactions between tumor cells and the stromal cells composing the tumor microenvironment. The human liver is a major site of tumors and metastases, but molecular identities ...
we addressed this limitation by describing the developmental trajectories of different cell types that make up the human liver at single-cell resolution. These transcriptomic analyses revealed that sequential cell-to-cell interactions direct functional maturation of hepatocytes, with non-parenchymal cells pl...
Here we apply single-cell and single-nucleus transcriptomics on healthy, hypertrophied (regenerating), and atrophied (embolized) human liver biopsies to explore cell states within this paradigm of human liver regeneration. The data reveal changes to cell type proportions, hepatocyte zonation, and interc...
et al. High resolution mapping of the tumor microenvironment using integrated single cell, spatial and in situ analysis. Nat. Commun. 14, 8353 (2023). Article CAS PubMed PubMed Central Google Scholar Ortiz, C. et al. Molecular atlas of the adult mouse brain. Sci. Adv. 6, eabb3446 (...
The human liver is an essential multifunctional organ. The incidence of liver diseases is rising and there are limited treatment options. However, the cellular composition of the liver remains poorly understood. Here we performed single-cell RNA sequenci
The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RN...
cell turnover differs between humans and mice. Using single-cell techniques and flow cytometry, we determine that the proportion of the protective resident liver myeloid cells, denoted liver myeloid cells 2 (LM2), decreases during obesity. Functional validation approaches using human 2D and 3D ...
cell turnover differs between humans and mice. Using single-cell techniques and flow cytometry, we determine that the proportion of the protective resident liver myeloid cells, denoted liver myeloid cells 2 (LM2), decreases during obesity. Functional validation approaches using human 2D and 3D ...
Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas Dilan Martínez-Torres , Valentina Maldonado & Fabián Segovia-Miranda Article 29 January 2024 | Open Access Comprehensive bile acid pool analysis during ex-vivo liver perfusion in a porcine model...
We here generated a single-cell atlas of intrahepatic T cells in PSC, a type of immune cells that has previously been involved in the pathogenesis of PSC. This atlas provides a valuable data source to the field. Using that atlas, we identified a population of liver-resident naive-like CD4...