Single-cell sequencing, as a novel bioanalysis technology, has significantly contributed to the understanding of the global cognition and dynamic changes in liver cancer. However, there is a lack of bibliometric analysis in this specific research area. Therefore, the objective of this study is to ...
6、对肿瘤区域的克隆型T细胞进行了分析,发现危重病人的克隆型Treg占据的比例更高,同时发现了这样一个亚群CD8+FOXP3+,分析克隆发现是,CD8+FOXP3-的细胞分化而来, Tregs and exhausted CD4 T cell clusters 共享很少,indicated the potential conversion from exhausted CD4 T cells to inducible Tregs。 最后看一下文...
但是目前治疗手段有限且免疫治疗缺乏临床成功。 3. 参与肿瘤发生发展的免疫细胞类型多样且异质性很强,只有对浸润淋巴细胞进行单细胞测序分析才能更好的理解复杂的肿瘤微环境,真正获得系统详尽的肿瘤免疫图谱,从而有助于肿瘤免疫疗法的发展及有效靶点和生物标志物的发现。 研究策略: 对六位未进行治疗的肝癌病人的肿瘤样本...
little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RNA sequencing. We provide the transcriptional profiles of 8444 parenchymal and non-parenchymal...
Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity and heterogeneity among PLCs remains challenging. Here, using single-cell RNA sequencing, spatial transc
Unimodal single-cell sequencing techniques have already revolutionised our understanding of the different layers of molecular hierarchy in the tumour microenvironment of HCC. By highlighting the cellular heterogeneity and the intricate interactions among cancer, immune and stromal cells before and during ...
And then the cellular atlas of RILI liver was generated by profiling 9,641 cells isolated from X-ray irradiated mice livers and control ones from RILI mice model using single-cell RNA sequencing (scRNA-seq). Seven cell types were identified, including B cells, natural killer cells, T ...
154]. Sorafenib-induced ferroptosis depends on the status of RB transcriptional co-repressor 1 (RB1), a key regulator in the cell cycle, and the loss of function of RB1 has been recognized as a common event in HCC [379380]. 7.2Ferroptosis in liver cancer therapy ...
Liver cancer arises from the evolutionary selection of the dynamic tumor microenvironment (TME), in which the tumor cell generally becomes more heterogeneous; however, the mechanisms of TME-mediated transcriptional diversity of liver cancer remain unclear. Here, we assess transcriptional diversity in 15...
Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing. Cell 169, 1342–1356 (2017). Article CAS PubMed Google Scholar Ma, L. et al. Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer. Cancer Cell 36, 418–430 (2019). Article CAS ...